Natural Products Insider

SEP-OCT 2018

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50 INSIDER September/October 2018 "The cardioprotective effects of ALA are mediated in part by a reduction in the production of infl ammatory cytokines." One review emphasized the role of omega-6 gamma linolenic acid (GLA) in modulating infl ammatory response, and hence its potential application as an anti-infl ammatory nutrient or adjuvant. 44 GLA works to limit pro-infl ammatory molecules while promoting anti- infl ammatory molecules directly on cells. 1 Plant-based sources rich in GLA include borage oil, black currant seed oil and evening primrose oil. Nena Dockery, technical services manager at Stratum Nutrition, suggested Ahifl ower ® (Buglossoides arvensis seed) as a sustainable plant source for a unique balance of omega-3 fatty acids, omega-6 GLA and omega-9. She pointed to 2018 research indicating EPA and DHA in providing support against infl ammaging, "a term coined to describe age-related chronic systemic infl ammation involved in the etiology of many age-related disorders." 45 High levels of circulating pro-infl ammatory cytokines are characteristic of infl ammaging. The results showed EPA and DHA therapy had a signifi cant lowering effect on levels of IL-6, IL-1β and TNF-α after four weeks of therapy and an even greater lowering effect after eight weeks of therapy. Further, after adjusting for baseline difference, the treatment group had signifi cantly lower levels of IL-6 compared to control. Tomato phytonutrients have been linked to potential benefi ts on infl ammation related to bone and joint health. One study examined whether carotenoid derivatives inhibit NF-kβ, as well as determining the molecular mechanism underpinning the inhibitory action. 46 Researchers found that lycopene preparations purifi ed from tomato extract (from Lycored) inhibited NF-kβ reporter gene activity. When considering bone and joint formulations, Karin Hermoni, Ph.D., head of science and nutrition at Lycored, suggested, "The mechanism of action of such an effect may involve the control of infl ammatory processes as well as the antioxidant properties of tomato phytonutrients. Of note, carotenoids such as lycopene act not only by quenching reactive oxygen species, but also by boosting the cell's own antioxidant defense mechanism." Methylsulfonylmethane (MSM) is a popular joint health ingredient boasting anti-infl ammatory activity. In a study examining the effect of MSM on murine macrophages, MSM demonstrated the ability to inhibit the expression of infl ammatory markers through the suppression of iNOS and COX-2 genes. 47 MSM also strongly inhibited the infl ammatory cytokines IL-6 and TNF-α, both key in producing an infl ammatory response to acute injury. MSM's inhibition of NF-kβ was identifi ed as a possible mechanism. MSM blocked the degradation of a key protein, essentially disabling the expression of various infl ammatory response mediators. In an in vitro study examining the effect of MSM on human chondrocyte cells, MSM demonstrated powerful IL-6 and IL-8 suppression by deactivating the protein Join us at SupplySide West • Booth #3373 • November 8-9, Mandalay Bay Hotel Las Vegas, NV PROMOTES JOINT COMFORT Perluxan ® softgels are a unique, premium quality supplement primarily used to support joint health and soothe aches from overexertion of everyday activities. Contact us today to add this unique botanical extract derived from hops to your product line. www.soft-gel.com These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Inflammation

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