Natural Products Insider

NOV-DEC 2018

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88 INSIDER November/December 2018 Reactive oxygen species (ROS) can damage cells and tissues through oxidation. Each cell in the human body can form 20 trillion ROS per day through normal metabolism and be attacked by these reactive molecules 10,000 times per day. 1 These unstable molecules can damage cells and tissues through oxidation. In a healthy human body, the antioxidant defense system keeps the generation of ROS and free radicals under control. However, these defenses grow weaker as we age, increasing the susceptibility of health conditions associated with oxidative stress. Supplementation with dietary antioxidants can help support the body's defenses and mitigate the harmful effects of ROS. ROS and free radicals play signifi cant roles in many neurological challenges. 2 The Brain and Oxidative Damage The brain is particularly vulnerable to oxidative damage from ROS due to certain physiological, functional and anatomical factors, 2 including: { Higher oxygen availability; { Modest antioxidant defenses; { Limited regenerative capacity; and { Multiple neurological cell types. To keep the brain functioning at its highest potential, it is important to keep ROS in check. Multiple studies have shown supplementation with antioxidants can help support the body's defenses and mitigate the harmful effects of ROS. Sourced from the microalgae Haematococcus pluvialis, astaxanthin can neutralize harmful ROS without generating pro-oxidants, which is a common side effect of other antioxidants. 3 Lab research has shown astaxanthin can cross the blood-retinal and blood-brain barriers with no adverse effects, enabling it to provide support to the central nervous system and minimize damage caused by free radicals. 4 Astaxanthin is different than other carotenoids because it can span the entire cell membrane—the exterior, interior and across the entire lipid layer. This full-cell coverage further aids in protecting against ROS and lipid peroxidation. Scientifi c Evidence for Astaxanthin in Brain Health A growing body of peer-reviewed research shows the general health benefi ts of astaxanthin supplementation, including the effects on cognitive function and brain health. Nakagawa et al. conducted a randomized, double-blind, placebo-controlled human trial to test for the effects of astaxanthin supplementation on phospholipid hydroperoxide (PLOOH), a substance that has been shown to accumulate abnormally in the red blood cells of dementia patients. 5 After 12 weeks of supplementation with either astaxanthin or a placebo, researchers found erythrocyte and plasma PLOOH concentrations were lower in the astaxanthin groups. Satoh et al. conducted a study that demonstrated astaxanthin is effective for managing age-related decline in cognitive and psychomotor functions. 6 Astaxanthin was shown to improve cognitive health and learning scores in a study of healthy middle-aged and elderly subjects with age-related forgetfulness conducted by Katagiri K et al. 7 These researchers studied the effects of astaxanthin supplementation on cognitive function. Ninety-six healthy middle-aged and elderly subjects with some level of age-related forgetfulness were included in the study and received either astaxanthin (6 mg/d or 12 mg/d) or a placebo for 12 weeks. Changes in cognitive performance were assessed using two standardized memory tests—CogHealth and the Groton Maze Learning Test (GMLT). CogHealth scores improved in the 12 mg/d group compared to other treatments, and GMLT scores improved earlier in the 6 mg/d and 12 mg/d groups than the placebo group. Satoh et al. conducted an open-label trial with 10 male subjects ages 50 to 69 that presented symptoms of mild cognitive impairment. 6 The 12-week study tested astaxanthin at a dose of 12 mg/d. Cognitive health parameters (CogHealth and P300) were assessed before administration, after six weeks and after 12 weeks. The authors concluded administration of astaxanthin may improve higher brain function, including cognition, attention, memory, information processing and resultant behavior in older individuals. The study also demonstrated astaxanthin at doses as high as 20 mg/d for four weeks did not produce side effects or safety concerns. Recommended dosages for astaxanthin range from 2-12 mg/day, depending on health needs. These and other recent scientifi c fi ndings demonstrate natural astaxanthin is an extremely potent scavenger of ROS and can help support cognitive function. The interest in astaxanthin as an ingredient in the cognitive health category is growing and will continue to grow as the relative ratio of older consumers increases. This development creates an opportunity for manufacturers to develop dietary supplements that can help people support brain function throughout life. Tryggvi Stefánsson, science manager, Algalif (, has a doctorate in microbiology and genetics from ETH Zurich in Switzerland. He joined Algalif in early 2014 and has led the company's R&D and scale-up department as science manager since 2015. Astaxanthin for Cognitive Health by Tryggvi Stefánsson, Ph.D. Cognitive Health For a list of references, email Astaxanthin may improve higher brain function, including cognition, attention, memory, information processing and resultant behavior in older individuals.

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