Natural Products Insider

NOV-DEC 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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† Results compared to baseline 1. Kalman DS, Feldman S, Samson A, Krieger DR. A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males. Clinical Pharm: Adv and Applica. 2015; 7:103- 109. 2. Rood-Ojalvo S, Sandler D, Veledar E, Komorowski J. The bene ts of inositol-stabilized arginine silicate as a workout ingredient. Journal of the International Society of Sports Nutrition. 2015;12(Suppl 1):P14. 3. Kalman D, Harvey PD, Perez Ojalvo S, Komorowski J. Randomized prospective double-blind studies to evaluate the cognitive effects of inositol-stabilized arginine silicate in healthy physically active adults. Nutrients. 2016;8(11):736. 4. Komorowski J, Perez Ojalvo S. A pharmacokinetic evaluation of the duration of effect of inositol-stabilized arginine silicate and arginine hydrochloride in healthy adult males. The FASEB Journal. 2016; 30(1) Supplement 690.17. 5. Kalman D, Perez Ojalvo S, Komorowski J. Comparison of cellular nitric oxide production from various sports nutrition ingredients. J Int Soc Sports Nutr. 2016;13 (Suppl 1):P33. ©2017 Nutrition 21, LLC Nitrosigine ® is a registered trademark of Nutrition 21, LLC. Nitrosigine is protected by a number of patents and pending patent applications on compositions, their manufacture, and/or their uses, including, but not limited to: U.S. Patent Nos.: 6,803,456 and 7,576,132. DRA1175102317 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Nitrosigine is the ingredient that crushes sales—get it now. Find out more at NUTRITION21.COM or email : info@Nutrition21.com INGREDIENT SUPERIORITY Clinically shown to significantly boost nitric oxide (N.O.) production 40+ substantiated claims support N.O., energy, focus, mental acuity, processing and recovery 19 studies support efficacy and safety Easy to formulate into powders, bars and beverages FDA New Dietary Ingredient (NDI) Notification GRAS affirmed at clinically substantiated dosages DRIVING DEMAND Consumer branded ingredient program generates 257 million yearly impressions: Print and digital Men's Fitness, Muscle & Fitness and Flex ads "In the News" press and publicity N.O. POWER FROM WITHIN. TM Nitrosigine vs. other ingredients: In Vitro Study 0.2 0.4 0.6 1.2 1.0 0.8 µM nitrite Nitrosigine Agmatine Sulfate L-Arginine Arginine AKG Citrulline Malate L-Citrulline † 5 *P<0.01 vs. other ingredients * M O R E N I T R I C OX I D E P RO D U CT I O N T H A N OT H E R I N G R E D I E N T S ® *1-5 *1 >

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