Natural Products Insider

NOV-DEC 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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94 INSIDER November/December 2018 The microbiota-gut-brain axis is a bidirectional network in which the brain directs activities in the gut and resident gut bacteria, in turn profoundly shaping brain development, behavior and mood. 1-5 It is now recognized that stress and mood disorders, such as depression and anxiety, are infl uenced by the health of the gut and the microbiome's modulation of systemic infl ammation. A new class of probiotics, known as psychobiotics, are being embraced by physicians as a nontoxic intervention for various psychiatric conditions. 6,7 In 2017, Wallace and Milev at the Queen's University in Canada conducted a systematic review of 10 clinical trials on probiotics and mood. 8 One study by Steenbergen and colleagues is noteworthy because the multispecies probiotic studied (as Ecologic Barrier from Winclove) signifi cantly reduced overall cognitive reactivity to depression—specifi cally, aggressive and ruminative thoughts, as assessed by the Leiden index of depression sensitivity (LEIDS-R). 9 To date, clinical trials on probiotics for depression and anxiety have been heterogeneous in terms of dosing, probiotic strain selection and length of treatment. Further randomized controlled clinical trials are warranted to validate the effi cacy of this promising intervention. Jeremy Appleton is a naturopathic physician and dietary supplement industry professional. An alumnus and former nutrition department chair of the National University of Naturopathic Medicine (NUNM), he is an author, educator and vice president of science and educa tion for SFI USA (sfi, which manufactures dietary supplements under the Klaire Labs brand. Mood and the Microbiome by Jeremy Appleton, N.D. +HUEDOO\

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