Natural Products Insider

NOV-DEC 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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100 INSIDER November/December 2018 "Products with ingredients such as glucosamine or curcumin that are widely used on the human side in dietary supplements are labeled differently than on the pet side," he explained, noting the tenets of the Dietary Supplement Health and Education Act of 1994 (DSHEA) don't apply to animal nutrition. "In some ways, the pet side is more tightly regulated than the human side." Cognitive Support Protecting and prolonging cognitive function is an important human focus and an emerging segment in the pet realm. Scientists have used canines to study cognition and Alzheimer's disease because it's believed dogs exhibit human-like aging patterns, according to Chemi Nutra's Buchanan-Hilliard. "Research has concluded that dogs develop a condition that resembles Alzheimer's disease, with the formation of β-amyloid plaques that is often referred to as canine cognitive decline (CCD) or canine cognitive dysfunction (CCD)," 2 she said. One phosphatidylserine (PS) ingredient (as SerinAid ® PS, from Chemi Nutra) may benefi t CCD because it is involved with the transmission of cell-to-cell communication and, therefore, may improve memory, concentration, focus and recall. 3 It targets brain neurotransmitters and helps to improve memory defi cits both in old animals and in elderly humans with various degrees of cognitive impairment and dementia. An alpha-glyceryl phosphoryl choline (A-GPC) nutrient (as AlphaSize ® A-GPC, from Chemi Nutra) also targets CCD, as well as agility, stress and calming for service animals, police dogs, military dogs and animals competing in agility events. 4 The choline in AlphaSize A-GPC supports the body's primary neurotransmitter compound used for both cognitive and physical functioning. This provides for gains in mental processing speed, strength and agility via rapid engagement of contractile muscle. Gastrointestinal (GI) Support For dogs, GI discomfort usually means they've eaten something they shouldn't have; for cats, it's typically traced to parasites in their prey. Either way, GI issues prompt many vet visits. Enzymes and probiotics can help pets with sensitive stomachs or other digestive system conditions by aiding in digestion and even addressing conditions like canine irritable bowel syndrome (IBS). 5 The next frontier in pet nutrition is shaping up to be supporting quality of life. Embria's Reyes said this could encompass everything from broad, preventive disease care to ephemeral aspects like mobility, coat, breathing and skin comfort. A fi nal expectation he shared is that heightened ingredient safety will become even more paramount. "Specifi cally," he concluded, "more pet supplement manufacturers will likely require safety data on the ingredients used for the target species." Joanna Cosgrove is a Pennsylvania-based freelance writer who has enjoyed covering the dynamic dietary supplement and healthy food and beverage industries for 20 years. Animal Nutrition For a list of references, email New Frontiers in Research Shiva Ayyadurai, founder and CEO of CytoSolve Inc., has a problem with biological academic research, and he devised a novel way to solve it. If there's one thing he's great at, it's solving problems. Ayyadurai holds four degrees from the Massachusetts Institute of Technology (MIT), including a doctorate in biological engineering. He started seven successful tech companies and holds the copyright to EMAIL, an electronic mail software. (Claims Ayyadurai invented email are controversial.) Now, he's working to improve animal and human health using an entirely unique approach to actionable research. He relates his issue with biological research to Buddha's elephant parable: Six men are blindfolded, asked to touch different parts of an elephant and explain what they think they're touching. All the men give different explanations because a trunk obviously gives a different impression than a tusk. This parable, he says, is like academia's approach to studying disease. "For example, joint health is a complex disease involving, among other things, cartilage degeneration and regeneration, infl ammation and oxidative stress," he said. "Academia is studying singular aspects of disease, identifying a magic bullet, but failing to connect all the moving parts of the disease." CytoSolve refi nes and connects research componentry like puzzle pieces, coupling human experts with artifi cial intelligence (AI) technology to create a more collaborative approach to biological research that examines the interconnected parts of disease. First, outdated research is discarded, and what's left is distilled down to core science. CytoSolve identifi es each "unique chemical reaction" associated with the discovery (the mechanisms that impact aspects of joint health, for instance) then converts them into connectible, bite-sized mathematical models. From there, a computer-friendly model is built that mathematically joins all the moving parts, ultimately resulting in a digital "cell" that Ayyadurai said is easier to scientifi cally manipulate than a real cell. "A computerized version of a cartilage cell can easily tell us what happens when we add MSM [methylsulfonylmethane] or zinc," he said. CytoSolve's models are updated periodically to account for new published research. One of the CytoSolve's fi rst commercial customers was Solid Gold, a pet food company that sought to legitimize its claims for improved skin health, coat health and oxidative stress. CytoSolve applied its model, confi rming which ingredients were responsible and how they delivered their benefi ts. CytoSolve recently partnered with the National Animal Supplement Council (NASC) to advance its work on other facets of animal health and has also begun applying its model to human conditions, including Alzheimer's disease.

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