Natural Products Insider

NOV-DEC 2018

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6 ASHWAGANDHA ADVANTAGE Exploring the Ashwagandha Advantage Ashwagandha: dŚĞ^ƚƌĞƐƐtĞŝŐŚƚDĂŶĂŐĞŵĞŶƚŽŶŶĞĐƟŽŶ THEORY: Ashwagandha (Withania somnifera Dunal) has a long history of use as an adaptogen, ŚĞůƉŝŶŐƚŽĐŽƵŶƚĞƌĂĐƚƚŚĞŶĞŐĂƟǀĞĞīĞĐƚƐŽĨ ƐƚƌĞƐƐŽŶƚŚĞďŽĚLJsĂƌŝŽƵƐďŝŽĂĐƟǀĞƐŝŶĂƐŚǁĂŐĂŶĚŚĂ have been shown in pre-clinical studies to impact ĐŽƌƟƐŽůůĞǀĞůƐĂŶĚĞdžĞƌƚĂŶdžŝŽůLJƟĐƉƌŽƉĞƌƟĞƐƐ previous research has connected stress to anxiety and ǁĞŝŐŚƚŐĂŝŶƚŚĞƋƵĞƐƟŽŶǁĂƐƌĂŝƐĞĚĂƐƚŽǁŚĞƚŚĞƌ ashwagandha root extract could improve general well-being and reduce physiological markers of stress that have been associated with obesity, reducing ŚƵŶŐĞƌĂŶĚƐƚƌĞƐƐĞĂƟŶŐďĞŚĂǀŝŽƌƐƚŽŝŵƉĂĐƚǁĞŝŐŚƚ and improve general well-being. PARAMETERS: dŚĞĞŝŐŚƚǁĞĞŬƉƌŽƐƉĞĐƟǀĞ clinical trial, conducted at a study center in Pune, India, involved 52 men and women between 18 and 60 years, who had a Perceived ^ƚƌĞƐƐ^ĐĂůĞ;W^^ƐĐŽƌĞŐƌĞĂƚĞƌƚŚĂŶϮϬƐƵŐŐĞƐƟŶŐĐŚƌŽŶŝĐƐƚƌĞƐƐ symptoms, and a body mass index (BMI) between 25 and 39.9. The trial was conducted using a random assignment, parallel-group, ĚŽƵďůĞďůŝŶĚƉůĂĐĞďŽĐŽŶƚƌŽůůĞĚĚĞƐŝŐŶŝŶǁŚŝĐŚƚŚĞƉĂƌƟĐŝƉĂŶƚƐ received a full-spectrum root extract of ashwagandha (as KSM-66 Ashwagandha from Ixoreal Biomed), receiving 300 mg per dose, twice daily, or placebo capsules twice daily. Primary outcomes were ŵĞĂƐƵƌĞĚǁŝƚŚƚŚĞW^^ƐĐŽƌĞĂŶĚ&ŽŽĚƌĂǀŝŶŐƐYƵĞƐƟŽŶŶĂŝƌĞdƌĂŝƚ (FCQ), with secondary outcomes related to weight, BMI, serum ĐŽƌƟƐŽůůĞǀĞůƐĂŶĚŚĂƉƉŝŶĞƐƐ ^ŽƵƌĐĞŚŽƵĚŚĂƌLJŚĂƩ ĂĐŚĂƌLJLJĂ^:ŽƐŚŝ<ŽĚLJtĞŝŐŚƚDĂŶĂŐĞŵĞŶƚŝŶĚƵůƚƐhŶĚĞƌŚƌŽŶŝĐ^ƚƌĞƐƐdŚƌŽƵŐŚdƌĞĂƚŵĞŶƚǁŝƚŚƐŚǁĂŐĂŶĚŚĂZŽŽƚdžƚƌĂĐƚŽƵďůĞůŝŶĚ ZĂŶĚŽŵŝnjĞĚWůĂĐĞŶƚƌŽůůĞĚdƌŝĂůJ Evid Based Complementary Altern Med.ϮϬϭϳ:ĂŶ•ϮϮ;ϭ•ϲϭϬϲK/ϭϬϭϭϳϳϮϭϱϲϱ ϳϮϭϲϲϰϭ ϯϬ IMPACT: In the United States, one-third of adults feel they are living with extreme stress, and nearly half of all adults ƌĞƉŽƌƚƚŚĞŝƌƐƚƌĞƐƐŚĂƐŝŶĐƌĞĂƐĞĚŽǀĞƌƚŚĞƉĂƐƚĮǀĞLJĞĂƌƐƉĞƌƚŚĞŵĞƌŝĐĂŶ/ŶƐƟƚƵƚĞŽĨ^ƚƌĞƐƐŚƌŽŶŝĐ ƐƚƌĞƐƐŚĂƐďĞĞŶůŝŶŬĞĚƚŽĂĚǀĞƌƐĞŚĞĂůƚŚĞīĞĐƚƐŽŶƚŚĞŚĞĂƌƚďƌĂŝŶĂŶĚŝŵŵƵŶĞĨƵŶĐƟŽŶ 1 and most recently to weight gain. In fact, a study released in February 2017 of more than 2,500 men and women ĨŽƵŶĚƚŚŽƐĞǁŝƚŚƚŚĞŚŝŐŚĞƐƚůĞǀĞůƐŽĨƚŚĞƐƚƌĞƐƐŚŽƌŵŽŶĞĐŽƌƟƐŽůŝŶŚĂŝƌƐĂŵƉůĞƐŚĂĚůĂƌŐĞƌǁĂŝƐƚƐŐƌĞĂƚĞƌ ǁĞŝŐŚƚĂŶĚĂŚŝŐŚĞƌD/•ŽďĞƐĞŝŶĚŝǀŝĚƵĂůƐŚĂĚƉĂƌƟĐƵůĂƌůLJŚŝŐŚĐŽƌƟƐŽůůĞǀĞůƐ 2 hƐŝŶŐĂŶĂƚƵƌĂůƐŽůƵƟŽŶ ƐƵĐŚĂƐĂƐŚǁĂŐĂŶĚŚĂƌŽŽƚĞdžƚƌĂĐƚƚŽŵŝƟŐĂƚĞƚŚĞƐƚƌĞƐƐǁĞŝŐŚƚĐŽŶŶĞĐƟŽŶƚŚƌŽƵŐŚĐŽŶƚƌŽůŽĨĐŽƌƟƐŽů ůĞǀĞůƐĐŽƵůĚŚĂǀĞĂƐŝŐŶŝĮĐĂŶƚŝŵƉĂĐƚŽŶŚĞĂůƚŚĐĂƌĞĐŽƐƚƐĂƐǁĞůůĂƐƉĞƌƐŽŶĂůŚĂƉƉŝŶĞƐƐůĞǀĞůƐ 1. Indian J Psychol Med. 2012. DOI: 10.4103/0253-7176.106022 2. Obesity. 23 Feb 2017. DOI: 10.1002/oby.21733 ŬƐŵϲϲĂƐŚǁĂŐĂŶĚŚĂĂĐŽŵ ^ŽƵƌĐĞ/ŶĨŽŐƌĂƉŚŝĐďƌŽƵŐŚƚƚŽLJŽƵďLJ OUTCOME: ƚƚŚĞĞŶĚŽĨƚŚĞĞŝŐŚƚǁĞĞŬƐƉĂƌƟĐŝƉĂŶƚƐƚĂŬŝŶŐĂƐŚǁĂŐĂŶĚŚĂŚĂĚĂ Researchers concluded: "Ashwagandha root extract can be useful for body-weight ŵĂŶĂŐĞŵĞŶƚŝŶƉĂƟĞŶƚƐĞdžƉĞƌŝĞŶĐŝŶŐĐŚƌŽŶŝĐƐƚƌĞƐƐ• 22 % decrease in mean ƐĞƌƵŵĐŽƌƟƐŽůůĞǀĞůƐ 3 % ƌĞĚƵĐƟŽŶ in body weight, compared to only 1.4% in the placebo group FCQ mean scoresĨŽƌWůĂŶŶŝŶŐWŽƐŝƟǀĞ ZĞŝŶĨŽƌĐĞŵĞŶƚEĞŐĂƟǀĞZĞŝŶĨŽƌĐĞŵĞŶƚ>ĂĐŬ ŽĨŽŶƚƌŽůŵŽƟŽŶĂŶĚŶǀŝƌŽŶŵĞŶƚǁĞƌĞĂůů ƌĞĚƵĐĞĚŝŶƚŚĞĂƐŚǁĂŐĂŶĚŚĂŐƌŽƵƉďLJĂƐƚĂƟƐƟĐĂůůLJ ƐŝŐŶŝĮĐĂŶƚĂŵŽƵŶƚƐƵŐŐĞƐƟŶŐƚŚĞƐƵďũĞĐƚƐƌĞũĞĐƚĞĚ the use of food as a method to cope with stress. On the primary outcome measured by PSS ƐĐŽƌĞƐƵďũĞĐƚƐƚĂŬŝŶŐĂƐŚǁĂŐĂŶĚŚĂĞdžŚŝďŝƚĞĚ ĂŵĂƌŬĞĚƌĞĚƵĐƟŽŶŝŶƚŚĞŵĞĂŶƐĐŽƌĞŽŶƚŚĞ W^^ĚƌŽƉƉŝŶŐĨƌŽŵϮϬϯƚŽϭϯϲƉŽƐƟŶŐĂ ƐŝŐŶŝĮĐĂŶƚůLJŐƌĞĂƚĞƌŝŵƉƌŽǀĞŵĞŶƚƚŚĂŶƚŚĞ placebo group.

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