Natural Products Insider

NOV-DEC 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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80 INSIDER November/December 2018 The nootropics industry is growing and changing, with an increasing array of products formulated for specifi c conditions. Elyse N. Lovett, marketing manager, Kyowa Hakko U.S.A. Inc. attributed this to growing knowledge about "the synergistic effects of ingredients and stronger health claims made when formulating with multiple ingredients." Development and Performance Maintaining focus can be challenging in a fast-paced society. Choline, Bacopa monnieri, inositol-stabilized arginine silicate and medium-chain triglycerides (MCTs) help cognitive performance. Choline helps synthesize cell membranes and neurotransmitters including acetylcholine. Acetylcholine is necessary for various aspects of brain and nervous system functioning, including memory and mood. 1,2 Most people consume less than the adequate intake (AI) for choline, 3 and | Research supports the role of choline, Bacopa monniera and nitric oxide-boosting ingredients in increasing cognitive performance. | Omega-3s, L-theanine and probiotics help improve mood by reducing impulsivity, aggression and depression. | Magnesium and spearmint were shown to preserve brain function in older adults by improving memory and alertness. Ingredients to Support Cognitive Performance and Mood by Marie Spano INSIDER's Take Cognitive Health though the body makes this nutrient, it isn't made in suffi cient quantities. 4 Good or excellent sources of choline include beef, poultry, soybeans and eggs. 5 Though long considered for its potential to attenuate degenerative and vascular cognitive decline, citicoline (CDP-choline) is an ingredient making waves in younger populations. According to Lovett, Kyowa Hakko U.S.A. has a proprietary form of citicoline "clinically studied to support mental energy, focus and attention in adolescents and adults." The herb Bacopa monniera is gaining attention for its potential cognitive benefi ts. Bacopa monniera inhibits the release of infl ammatory cytokines in the brain and repairs damaged neurons. 6,7 Meta analyses show bacopa can improve memory free recall 8 and reaction time. 9 Nitric oxide (NO) production declines with age. This short-lived gas opens blood vessels for greater blood fl ow, oxygen and nutrient delivery to tissues. According to James Komorowski, chief science offi cer, Nutrition 21, an inositol- stabilized arginine silicate (the branded ingredient Nitrosigine) increased NO production more than other NO-stimulating compounds such as arginine. In a double- blind, crossover study in healthy males, 1,500 mg/d of Nitrosigine for two weeks led to faster cognitive processing speed, focus and mental acuity after exhaustive exercise compared to placebo. 10 For those on the very high-fat ketogenic diet, MCTs may be attractive. Clinical studies show MCTs increase ketone body production, a source of energy for the brain, more rapidly than other fats such as coconut oil. 11,12 Mood According to Kara Landau, founder of Uplift Food – Good Mood Food, "mood-supportive nutrients are often shown to either be those associated with reducing internal infl ammation or those that stimulate mood-calming hormone release." Growing awareness of the link between gut and brain health has led to increased interest in supporting gut health in hopes of impacting the brain. The long-chain omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are praised for mood support. As components of brain cell membranes, fatty acids infl uence brain functioning. Diets low in omega-3 fatty acids result in disturbed neural functioning. 13 Evidence supports the use of high-dose omega-3 fatty acids to treat impulsivity, aggression and borderline personality disorders. 14

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