Natural Products Insider

JAN-FEB 2019

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8 INSIDER January/February 2019 Scan Here microbiome confi gurations, calling for personalized adjustment of universal recommendations." Research further demonstrated the impact of diet on the microbiome. Long-term diets are strongly associated with enterotypes distinguished primarily by levels of Bacteroides (protein and animal fat) and Prevotella (carbohydrates). 8 Though initiation of a high-fat/low-fi ber or low-fat/high-fi ber diet caused a detectable change of the microbiome within 24 hours, the participants' enterotype identities remained stable during the 10-day, controlled-feeding study, suggesting alternative enterotype states are associated with a long-term diet. Applying technology is another step toward realizing the potential of recent scientifi c discoveries. A 2015 study by Zeevi et al. continuously monitored week-long glucose levels in an 800-person cohort, measured responses to 46,898 meals and found high variability in the response to identical meals. 9 Researchers devised a machine-learning algorithm that integrates blood parameters, dietary habits, anthropometrics, physical activity and gut microbiota measured in the cohort and showed that it accurately predicts personalized postprandial glycemic response to real-life meals. The predictions were validated in an independent 100-person cohort. Finally, a blinded, randomized, controlled dietary intervention based on this algorithm resulted in signifi cantly lower postprandial responses and consistent alterations to gut microbiota confi guration. Commenting on the fi ndings, Bashiardes S et al. wrote, "Authors developed a revolutionary algorithm for predicting postprandial glucose responses by integrating microbiome composition, blood tests and antropometrics of 1,000 people. This is the fi rst study that utilizes a machine learning approach and microbiome information for personally tailored diet intervention." 10 Me-tabolomics Metabolomics is the study of chemical processes involving metabolites, the intermediate end product of metabolism. Metabolomics is also an area of rapid scientifi c development, according to Cooper. "Our ability to track changes in genetic expression via lifestyle choices has been dependent upon correlating those changes against diaries kept by subjects on food consumption, estimates on toxin exposure, sleep variation and other lifestyle factors," she explained, adding that these data, even when collected in a clinical setting, "are notorious for inadequacies and errors." She cited a common example: Subjects who estimate too low on food consumption and too high on hours of sleep. "We are looking for nuances in genetic expression using very sophisticated tools against imprecisely measured changes in diet and environmental exposure using archaic and inaccurate methods." Metabolomics, she said, has the potential to make good such clinical faux pas. "The science of metabolomics is going to solve all of these quandaries and exponentially advance its sister sciences of epigenetics, personalized nutrition and precision medicine," she said. "Instead of asking you what you ate, we are going to be able to look at a massive number of new biomarkers and tell you what you ate with great precision." And developments are already underway. In the past, Cooper said routine testing evaluated roughly 30 biomarkers. "Today, laboratory testing is available to most people that can test about 300 of the 800 biomarkers we have identifi ed. Tomorrow there will be more than 100,000 metabolites identifi ed, not counting thousands more that are the products of our microbiome bacterial metabolism," she said. Driving Solutions Forward Despite recent discoveries and advancements, many uncertainties in the world of personalized nutrition remain, one of them being: how to create effective, personalized solutions. But uncertainty, Cooper said, is no reason to withdraw. "If you are overwhelmed with the logistics of DNA, fecal microbiome or metabolome testing, or if you are stymied by the development of your own proprietary self-quantifi cation device, you should not abandon the concept of personalized nutrition," she advised. Instead, companies can take "baby steps" toward personalized nutrition to speak to consumers on a more personalized level. "Even if the product is for 'everyone,' it needs to be described to each consumer in terms of why it is specifi cally for them and might include: specialized content, targeted messaging, personalized dosing instructions, unique dosage vehicles, lifestyle advice and integration with other health platforms and/ or self-quantifi cation devices and the management of big data," Cooper said. Personalization via Customization One way to speak to consumers on a more personalized level is by creating semi-custom products that meet their dietary or lifestyle needs. Winner of the 2018 SupplySide West Editor's Choice Awards in the digestive health supplement category was Pure Essence for its Real-Zymes™ line of digestive enzymes. These enzyme supplements are customized to fi t personal needs, offering nine formulas covering popular diets such as Atkins, Paleo and Mediterranean, Keto, Vegetarian and an All-American. naturalproductsinsider.com/vitamins-minerals/ image-gallery-2018-supplyside-editors-choice- awards-supplements-winners Looking forward, one clear conclusion about the future of personalized nutrition is it's going to change. "The progress we've made in nutrigenomics is phenomenal, and there's a lot of information that can help now, but there is a wealth of new information still to be had," said Lois Nahirney, Ph.D., president and CEO, dnaPower, a Canada- based DNA health testing lab. Supplements: Personalized Nutrition For a list of references, email references@naturalproductsinsider.com

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