Natural Products Insider

MAR-APR 2019

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12 INSIDER March/April 2019 A long-standing challenge facing curcumin is its inherent poor bioavailability. "There are several characteristics of turmeric and its active curcuminoids that hinder effi cacy in the human body," Dockery explained. "It has poor solubility in an aqueous environment such as the human gut, it is not readily absorbed through the intestinal wall, and it is rapidly metabolized and eliminated from systemic circulation." This has led to an increasing number of trademarked curcumin ingredients that incorporate new technologies to overcome one or more of these obstacles, she said. For example, Stratum Nutrition's BioCurc ® is a proprietary curcumin liquid droplet micromicellar (CLDM) formulation designed to address both bioavailability challenges and the rapid metabolism of standard 95 percent curcumin ingredients. Offering curcumin in liquid micelle or micronized powder form has shown improved bioavailability. In a crossover study, healthy subjects took a single oral dose of 500 mg curcuminoids as native powder, micronized powder, or liquid micelles. 15 Blood and urine samples were collected for 24 hours and total curcuminoids and safety parameters were quantifi ed. Based on the area under the plasma concentration-time curve (AUC), the micronized curcumin was 14-, 5- and 9-fold and micellar curcumin 277-, 114- and 185-fold better bioavailable than native curcumin in women, men and all subjects, respectively. IM pointed to recent research showing the bioavailability of a formulation depends on its ability to deliver free, or unconjugated, curcuminoids into plasma. 16,17,18 "Since the majority of the currently bioavailable formulations are based on the plasma availability of glucuronide/sulfate metabolites of curcumin, their 'number of folds' claims are often misleading," 19 he said. "So, it is important to investigate the amount of curcuminoids in plasma as bioactive free form and the ratio of the free curcuminoids to the conjugated curcuminoids (FCR) should be considered more than the 'number of folds' of bioavailability enhancement over standard curcumin 95 percent." A water-based process of combination of curcumin with fenugreek dietary fi ber (as CurQfen ® , from Akay) has shown enhanced free curcuminoids bioavailability, enhanced clinical effi cacy and improved blood brain barrier-permeability. 20 However, argued Sreeraj Gopi, Ph.D., chief scientifi c offi cer, Aurea Biolabs, curcumin ingredient innovations often concentrate "only on curcumin and overlook the health benefi ts of turmeric molecules (other than curcumin). These non- curcuminoids such as turmeric proteins (turmerin), turmeric polysaccharides, turmerones, elemene, furanodiene, bisacurone, germacrone, calebin A, curdione and cyclocurcumin favor the therapeutic potential of turmeric which is backed by evidence from famous Ayurveda." Aurea Biolabs' Cureit ® is a bioavailable formulation of curcumin designed to Supplements: Curcumin

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