Natural Products Insider

MAY-JUN 2019

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8 INSIDER May /June 2019 mechanisms, ResistAid indirectly supported the immune system via lactic acid- producing bacteria and bacterial constituents on immune cells, production of short-chain fatty acids (SCFAs) and binding to SCFA receptors on leucocytes; directly by supporting the activity of NK cells, cytokines and macrophages; 5,6,7 and via enhanced antioxidant capacity that may improve immunity. 8 Beta-glucan derived from Euglena gracilis algae (as BetaVia Complete or BetaVia Pure, from Kemin Human Nutrition and Health) has been shown in preclinical and clinical research to support immune health by priming immune cells and promoting immune cell signaling. 9,10 In a new 90-day randomized, double- blind, placebo-controlled clinical trial awaiting publication, BetaVia Complete reduced upper respiratory tract infection (URTI) symptoms in healthy adults by 70 percent, led to 3.3 fewer sick days and 10 fewer URTI symptoms compared to placebo. Information was collected via self-reporting using the Wisconsin Upper Respiratory Symptoms Survey (WURSS). Probiotics Power Authors of the Cell study pointed to various nonheritable infl uences on the immune system, including the microbiome. 3 "The microbiome also clearly has a major infl uence on the immune system," 11 they wrote, "and shifts in its composition might cause signifi cant changes in the immune system." Supplementation with probiotic bacteria has been shown to benefi t immunity. According to a 2017 publication, certain probiotic strains infl uenced both innate and acquired immune response at the gene expression level. 12 The study used human expression microarray chips in an in vitro intestinal epithelial cell model to determine the impact of the strains on toll-like receptor 3 (TLR3)-mediated infl ammation. A probiotic strain of Bacillus coagulans (as Bacillus coagulans GBI-30, 6086, [Ganeden BC30 ® ] from Kerry Functional Ingredients & Actives) offers immune- boosting benefi ts. In a controlled study of 10 participants, 30 days of supplementation with the probiotic strain increased T cell production of TNF-alpha in participants after exposure to adenovirus and infl uenza A. 13 Building on these results, researchers evaluated the effect of GanedenBC30 on immunological marker levels following viral exposure, and found a statistically signifi cant difference in IL-8 levels, an indicator of innate immune system activity, levels after infl uenza A exposure, along with interferon gamma (IFN-gamma), after adenovirus exposure. 14 In recent research, daily consumption of GanedenBC30 by adults between ages 65 and 80 increased benefi cial groups of bacteria in the human gut and potentially increases production of anti-infl ammatory cytokines. 15 A probiotic formulation containing Bifi dobacterium lactis Bl-04™ (from DuPont Nutrition & Health) has been shown to support upper respiratory tract health and immunity by helping to produce higher levels of IL-8. 16 In a 2017 publication, Bl-04 at a dose of 2 billion colony forming units (CFUs) per day infl uenced the infl ammatory response to rhinovirus infection. 17 Subjects who took the Bl-04 probiotic supplement had a decreased amount of rhinovirus in their nasal washes during infection. Athlete Support Strenuous activity has been linked to decreased immune performance, which makes immune support supplements of great importance to athletes. "While exercise may boost immune function, strenuous training can exhaust the immune system and hinder the innate immune response," said Tim Hammond, vice president of sales & marketing, Bergstrom Nutrition/OptiMSM ® . "Viruses and bacteria may gain a foothold during this open window of altered immunity and lead to potential illness or downtime away from training." Methylsulfonylmethane (MSM as OptiMSM, from Bergstrom Nutrition) has been shown to support the innate immune system following exhaustive exercise, 18 and showed lower serum levels of infl ammatory markers post-exercise, 19 which "indicated that OptiMSM conserved a natural and healthy immune system after physical stress," Hammond said. In a new study, a proprietary baker's yeast beta 1,3/1,6 glucan (as Wellmune ® , from Kerry) decreased severity of URTIs among marathoners and fewer missed post-marathon workouts for those consuming Wellmune daily in a dairy-based beverage." 20 The results provide a greater understanding of Wellmune's ability to help strengthen the immune system when consuming the ingredient through a beverage product, said Don Cox, research and development (R&D) director – Wellmune and GanedenBC30, Kerry Functional Ingredients & Actives. Absorbed by specialized immune tissue in the gut, Wellmune binds to neutrophils, enabling them to move more quickly to recognize and kill foreign challenges. Beyond athletes, these effects are documented in several studies in a range of populations, including children in a day care setting, 21 high-stress populations 22 and Montana's Wildland Firefi ghters. 23 A combination of Bifi dobacterium lactis Bi-07 ® and Lactobacillus acidophilus NCFM ® (as HOWARU ® Protect Sport, from DuPont Nutrition & Health) consumed daily over a fi ve-month period was shown to reduce the risk of an upper respiratory illness and delay time to respiratory tract illness compared to placebo in physically active adults. The study showed signifi cantly extended exercise duration and signifi cantly improved training duration. 24 Supplementation with probiotic strain L. helveticus LAFTI ® L10 (from Lallemand Health Solutions) in elite athletes signifi cantly shortened the average duration of URTI-like episodes by 3.4 days and signifi cantly decreased the number of symptoms by around 29 percent in a 2016 publication by Marinkovic et al. 25 Based on a sub-analysis of the 2016 study, Michalickova et al. published a second paper on LAFTI L10 in 2017 focused on the salivary biomarkers of immunity. 26 Results showed total concentration of sIgA, a secretory form of IgA, was maintained in the LAFTI L10 group vs. a signifi cant reduction of 35 percent in the placebo group. In 2018, a third study on the probiotic supplement in elite athletes and its impact on pro- and antioxidant markers in the blood found markers of oxidative stress were decreased in the LAFTI L10 group and not in the placebo. 27 Supplements: Immune Health For a list of references, email

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