Natural Products Insider

JUL-AUG 2019

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8 INSIDER July /August 2019 mice that were prone to display symptoms similar to Alzheimer's disease a choline diet while pregnant and lactating. The mice born of these pregnancies were then fed a normal diet and bred to examine the possible impact on a second generation of mice. Researchers found the fi rst generation born of "high choline" mice showed improvements in spatial memory relative to the control group, and the effect persisted into the second generation, as well. "This novel research is the fi rst test to demonstrate that the cognitive benefi ts of maternal choline supplementation may be transgenerational, independent of the choline intake of the offspring," Druke explained. Curcumin's (Curcuma longa) ability to manage infl ammation and oxidative stress has led researchers to study its effects on cognitive decline. "The central nervous system also contains polyunsaturated fatty acids [PUFAs], which can be vulnerable to oxidative stress and infl ammation," explained Mariko Hill, product development executive at Gencor. "By lowering these two factors, curcumin may also be vital to maintaining cognitive function. Lastly, curcumin is also known to cross the blood- brain barrier; 10 thereby it could be a useful tool in managing neuroinfl ammation." Gencor's HydroCurc, an extract of C. longa (standardized to 95 percent) using LipiSperse delivery technology (from Pharmako Biotechnologies) to increase bioavailability and functionality, is currently under investigation by researchers at the National Institute of Complementary Medicine (NICM) at Western Sydney University for its potential to reduce infl ammation in the brain. Loukiana Chatzinasiou, product manager at Sibelius Natural Products, pointed to 2015 research showing maintaining good sleep quality promotes better cognitive functioning and helps protect against age-related cognitive decline. 11 Roman chamomile is an ingredient shown to improve sleep and have anti-infl ammatory and muscle-relaxing effects. A 2017 study conducted on 60 elderly volunteers concluded a specifi c chamomile extract signifi cantly improved sleep quality. 12 Research shows bacopa (as Bacognize, from Verdure Sciences) may help promote better quality of sleep and support the regulation of sleep cycles by interacting with serotonin receptors, helping to alleviate stress, and providing antioxidation benefi ts. 13 Activity and Wellness "A reduction in one's physical activity level and functional fi tness has also been identifi ed as a natural part of the aging process and is thought to occur largely as a result of decreased muscle strength and changes in body fat percentage, fl exibility, agility and endurance," Marshall explained. 14 Baby Boomers and older generations are turning to exercise and diet to stay healthy in their twilight years. Several sports nutrition ingredients offer researched benefi ts to help these consumers stay fi t and recover from exercise. Older adults have increased protein needs aside from any exercise-related needs. Adults can start experiencing age- related muscle loss in their 40s. Further, masters athletes (age 40 and older) have lower rates of muscle protein synthesis (MPS) than do younger athletes, leading to poor muscle protein repair and modeling, according to Australian research. 15 A 2016 study showed Pycnogenol's benefi ts for curbing age-related muscle loss. The study reported signifi cant improvement in muscular function and reduction of oxidative stress in healthy adults ages 70 to 78. 16 High-intensity resistance training combined with protein ingestion has also been found useful in helping older adults—especially those who typically forgo such exercise— achieve and maintain stronger, leaner bodies. A study on non-resistance-trained women (ages 52 to 63) demonstrated both whey and casein intake in combination with high-intensity resistance training (three sets, 10 repetitions at 75 percent of 1RM [one-rep maximum]) improved body composition, muscular strength and muscular endurance. 17 Soy protein can help bump MPS in the short term, but it might not have the same ability as whey to promote MPS longer term. 18 Brands are slowly targeting healthy, active aging consumers on protein products, according to proprietary data from New Hope Network's NEXT Trend Database, which tracks all products exhibited at the Natural Products Expo West and Expo East trade shows. Protein mixes and powders with an aging claim accounted for only 0.54% of all protein mixes and powders at the Expo shows in 2016, but this increased greatly to 6.35% in 2018. In 2016, only 1 of 185 protein mixes and powders carried an aging claim compared to 16 of 252 protein mixes and powders in 2018. While these overall numbers are low, the growth indicates brands are starting to see value in touting protein for healthy aging. Healthy bones and joints are also important to maintaining active lifestyles. One of the biggest threats to bone health as people age is osteoporosis, a condition where new bone creation doesn't keep up with old bone removal, resulting in increasingly porous bones. Porous bones are more prone to fractures from falls, strains or bumps. "The balance between bone formation and bone loss changes after peak bone mass is reached, around 30 years old," 19 explained Samantha Ford, business development director at AIDP. "Usually, men and women have the same speed of bone loss in mid-life. However, women can lose up to 20 percent or more of their bone in the fi ve to seven years after menopause [according to the National Osteoporosis Foundation]." In response to the lopsided instances of bone loss in older women, a good amount of research is centered around maintaining and recovering bone density in female participants. Supplements: Healthy Aging

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