Natural Products Insider

APR 2012

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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Patent Triumphs and Battles The U.S. Patent and Trademark Office (USPTO) issued a patent (No. RE42645E) to Albert B. Crum, M.D., Ph.D., for a method describing the physiological synthesis of glutathione, a tripeptide that helps regulate the immune system. The patent, "Nutritional or Therapeutic Compositions and Methods to Increase Bodily Glutathione Levels" is the basis of the dietary supplement Immune Formulation 200® from the ProImmune Co. LLC. ParActin, a proprietary compound from HP Ingredients, has garnered a U.S. Patent (No. 8,084,495 B2) for its extraction of labdane diterpenes from the herb Andrographis paniculata, which are useful in the treatment of autoimmune diseases and Alzheimer's Disease by activation for PPAR-gamma receptors; PPARy is the key regulator of the immune and inflammatory response. Polyphenolics, a division of Constellation Brands, repor ted USPTO confirmed a four th patent (No. 8,075,929) for its MegaNatural-BP grape seed extract (GSE). The patent covers the production process for the structurally unique GSE. The USPTO granted Aker BioMarine's request for reexamination of another krill patent (No.8,057,825) held by Neptune Technologies & Bioressources, which covers methods of reducing cholesterol, platelet adhesion and plaque formation by the administration of krill oil. The USPTO granted the request on the 12 claims submitted by Aker BioMarine, which also provided the office with multiple references. This motion comes a few weeks after the companies agreed to a litigation cease-fire in the case involving other krill patents. Magnesium Lowers Stroke Risk Dietary magnesium intake was inversely associated with risk of ischemic stroke (strokes caused by blood clots in the brain) in a recent meta-analysis from the Karolinska Institutet in Sweden (Am J Clin Nutr. 2012 Feb;95(2):362-6). Researchers conducted a dose- response meta-analysis using seven prospective studies from January 1966 through September 2011 with 6,477 cases of stroke and 241,378 participants. They found a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg/d of magnesium was associated with an 8-percent reduction in risk of total stroke. Magnesium intake was inversely associated with risk of ischemic stroke, but not intracerebral hemorrhage or subarachnoid hemorrhage. Ischemic stroke occurs as a result of an obstruction within a blood vessel, a partial or total blockage of an artery supplying blood to the brain. It accounts for 88 percent of all stroke cases, and according to the Internet Stroke Center, stroke is the third highest cause of death in the United States. Previous studies have reported low levels of magnesium are associated with an increased rick of stroke. Why does a nice guy like him enjoy torturing your products? Yogesh Patel, QC Director Yogesh really loves to dish it out to the tablets, capsules and powders we produce for our clients. He's our director of Quality Control and to him nothing is immune. In our state-of-the-art laboratory, he weighs and analyzes blends and ingredients every step of the way. He crumbles, heats and crushes tablets and capsules. He subjects them to infrared and ultraviolet testing and all sorts of other indignities. But his toughness is worth it. Because that kind of treatment has earned Paragon GMP certifications from NSF International and NPA. And organic certification from QAI. Your products may not be crazy about how Yogesh treats them. But our clients sure are. • ::: 3$5$*21/$%686$ &20 Custom supplement manufacturers since 1971. 8 INSIDER ¥ APRIL 2012 IN THE NEWS

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