Natural Products Insider

APR 2012

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Pterostilbene, a compound found in small red berries, has been used for millennia in Ayurvedic medicine as a blood sugar management tool . Pterostilbene is also found in the Indian kino tree (Pterocarpus marsupium), and this tree was studied in a 1978 trial that reported 5 g/d tid of its extract reduced blood sugar levels af ter three weeks compared to baseline.17 pterostilbene significantly lowered the blood glucose level of hyperglycemic rats, and the ef fect was comparable to that of metformin, a prescription drug used to treat type 2 diabetes.18 More recent research on isolated In a 1997 study, Pterocarpus marsupium and pterostilbene found it decreased glucose levels in diabetic rats and also increased insulin production. Si lbinolĀ® (f rom Sabinsa Corp.), a standardized extract of P. marsupium, has been the subject of two unpublished cl inical t rials. The Indian Counci l of Medical Research found P. marsupium h e l p ed co n t r ol bo th fa s t i ng an d postprandial blood glucose in 67 of 93 newly diagnosed non-insulin dependent diabetes patients between 35 and 60 years old. And another study on 20 patients with matur i ty onset diabetes repor ted P. marsupium at 5 g tid af ter meals reduced fasting and postprandial blood sugar levels comparable with the conventional drug therapies. More recent research on isolated p te ro s t i l b e n e found it d e c r e ased glucose levels in diabet ic rats and also increased insulin product ion. 19 Pterostilbene also acted as a protective antioxidant in type 2 diabetic rats by Register for the Natural Products INSIDER Website for exclusive access to: t 3FQPSUT t 8FCJOBST t 8FFLMZ & OFXTMFUUFS t %JHJUBM *TTVFT t 4PMVUJPO $FOUFST t *NNFSTJPO $FOUFST t .PSF 7JTJU PS TDBO UIF 23 DPEF UP CFDPNF B NFNCFS UPEBZ 26 INSIDER Ā„ APRIL 2012 increasing the activi ty of superoxide dismutase (SOD) and glutathione, and normalizing lipid peroxidation in livers and kidneys.20 Lagerstroemia speciosa L., commonly known as banaba or crepe myr t le, contains corosolic acid, a key component that has shown anti-diabetic properties. A 2004 Japanese study found corosolic acid reduced blood glucose levels in KK-Ay mice (an animal model of type 2 diabetes) four hours after single oral administration compared with the control group, and it also increased muscle facilitative glucose transporter isoform 4 (GLUT4), signifying it helps facilitate the transfer of glucose from the blood to muscles.21 Banaba also contains the ellagitannin lagerstroemin, which was shown to cause insul in- like actions in rat adipocytes, including increasing the rate of glucose uptake.22 DIABETES

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