Natural Products Insider

APR 2012

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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With carb inhibitors, digestive enzymes allow an individual to eat a reasonable amount of carbohydrate, but lessen or at least slow the absorption of refined carbohydrates into the bloodstream. Carb blockers may also reduce the amount of calories absorbed. A study from SIBR Research Inc., Bradenton, FL, found a banaba leaf extract, standardized to 1-percent corosolic acid in a sof tgel capsule formulation (as GlucoFit™, from Soft Gel Technologies Inc.) showed a 30-percent decrease in blood glucose levels compared to a 20-percent drop seen with dry-powder filled hard gelatin capsule formulation, suggesting the soft gel formulation has a better bioavailability.23 Another extract from banaba leaves, standardized to 18-percent corosolic acid, has been the subject of two unpublished clinical trials. In the first study, one softgel of GlucoHelp™ (from Soft Gel Technologies Inc.) per day, providing 10 mg of corosolic acid, for one week reduced fasting blood glucose, as well as postprandial blood glucose 30, 60 and 120 minutes after eating a starchy meal. While none of the subjects in the trial had diabetes, those with pre-diabetes (fasting blood glucose levels of 110 mg/dL or above) saw the greatest decreases in blood glucose—15 percent after one week and 21 percent after two weeks. In the second study, a randomized, placebo-controlled clinical trial found one daily soft gel of GlucoHelp for 30 days reduced fasting and two-hour postprandial blood glucose levels compared to control. An analysis of the leaves of Eriobotrya japonica, otherwise known as loquat, shows it too contains corosol ic acid along wi th torment ic acid, which also possesses antidiabetic actions.24 A 2010 study from Taiwan found loquat reversed insulin resistance and reduced hyperglycemia caused by a high-fat diet in mice.25 And a 2008 study reported Eriobotrya japonica seeds lowered serum insulin and blood glucose levels in type 2 diabetic rats and mice compared to controls.26 Coccinia indica (also known as Coccinia cordifolia), an herb growing abundantly in India, has been used in traditional treatment of diabetes, but it's also been the subject of clinical trials. In 2008, a double blind, placebo-controlled, randomized trial found 1 g/d of an alcoholic extract of the herb for 90 days decreased the fasting, postprandial blood glucose and A1C levels in patients with mild diabetes.27 In 2011, a rat study found petroleum-ether, ethyl acetate and chloroform fractions isolated from ethanolic extract of the leaves of Coccinia cordifolia Linn. (150 mg/kg body weight) reduced blood glucose levels in normoglycemic rats.28 The seeds of the jambol tree (Syzygium cumini), native to eastern India, contain the chemical constituents gallic acid, oxalic acid, antioxidants, sterols and ellagic acid; the combination may be the right mix to create a antihyperglycemic effect. A proprietary extract of the jambol tree (as JamboLean®, from Roxlor International) was found to act at the gene level to block glucose absorpt ion, provide phytochemicals believed to have a role in diabetic control, and reduce inflammation and obesity in an in vitro, unpublished study sponsored by Roxlor. Plant-Based Carb Blockers Some ingredients are known to slow or inhibit the absorption of carbohydrates, which reduces the need for insulin in the body. With carb inhibitors, digestive From start to finish you can expect comprehensive communication and responsive service as your product goes through all the phases of development. ® Pacific Nutritional We're at Your Service! Pacific Nutritional, Inc. 360-253-3197 Custom Contract Manufacturing Since 1980. naturalproductsinsider ¡ com 29 Inc.

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