Natural Products Insider

APR 2012

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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Page 34 of 60

A 1996 Japanese study on the monosaccharide L-arabinose reported the naturally occurring, but poorly absorbed, sugar suppressed the glycemic response after sucrose ingestion by inhibition of sucrase activity. enzymes allow an individual to eat a reasonable amount of carbohydrate, but lessen or at least slow the absorption of refined carbohydrates into the bloodstream. Carb blockers may also reduce the amount of calories absorbed. White bean (Phaseolus vulgaris) extract can help diabetes sufferers navigate the world of white bread and refined grains as it can inhibit absorpt ion of the carbohydrate amylase and a 5-carbon sugar (L-arabinose) to inhibit sucrose development. In a 2000 Norwegian randomized, placebo-controlled, double blind study, obese patients who ingested white bean extract experienced significant weight and fat loss.29 Seven years later, an Italian randomized, double blind, placebo- controlled study found after 30 days, subjects receiving a standardized white kidney bean extract (445 mg) with a carbohydrate-rich, 2,000- to 2,200-calorie diet had significantly greater reduction of body weight, body mass index (BMI), fat mass, adipose tissue thickness, and waist/hip/thigh circumferences while maintaining lean body mass compared to subjects receiving placebo.30 A propr ietary, standardized extract of the whi te kidney bean (as Phase 2 Starch Neutralizer® from Pharmachem Laboratories) has been the subject of numerous studies conducted by Jay Udani, M.D., at Medicus Research LLC. In 2004, he and a team of researchers at the Universi ty of Cal i fornia, Los Angeles, repor ted clinical trends for weight loss and a decrease in triglycerides af ter obese subjects took 1,500 mg/d Phase 2, although statistical significance was not reached.31 In 2007, Udani conducted another study and found subjects who consumed 1,000 mg/d of Phase 2 and followed a multi-component weight- loss program, including diet, exercise and behavioral intervention, significantly reduced their weight and waist size in four weeks.32 "The country a product comes from is not a reliable indicator of its quality." Community 30 INSIDER ¥ APRIL 2012 DIABETES Get in on the discussion.

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