Natural Products Insider

NOV-DEC 2016

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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38 INSIDER November/December 2016 alginates and modifi ed starches are commonly used in hydrophilic matrices. 13 Polyethylene, polyvinyl chloride, ethyl cellulose and acrylates are used in hydrophobic matrices. 14 Several physicochemical factors may infl uence the release rate of actives from the matrix. Dose size, ionization, partition coeffi cient and aqueous solubility of the actives are paramount and should be considered when developing such matrices. 15 In vitro assessment of the matrix during product development is equally crucial for a successful ER delivery system. To achieve this objective, a dissolution profi le of the formulation is usually studied by using the United States Pharmacopeia (USP) dissolution apparatus to verify the desired in vitro release rate. A typical reservoir system consists of a core, containing active ingredient(s), surrounded by a hydrophobic rate- controlling fi lm. A reservoir system is mostly used to modify the release rate of highly water-soluble materials. In this delivery system, the materials are either coated or microencapsulated with slowly dissolving materials such as cellulose and polyethylene glycol. Solubility and thickness of the coating are major contributing factors in controlling the dissolution rate of such systems. 17 The basic principle of an osmotic system is similar to a reservoir system— the main difference being that the core in an osmotic system is surrounded by a semi-permeable membrane with an orifi ce for the release of bioactive materials. The release of the active from such systems is mainly governed by solubility and osmotic pressure of the core; size of the delivery orifi ce; and physicochemical characteristics of the rate-limiting, semi-permeable membrane. 18 The market for MR delivery systems in the nutraceutical industry has come a long way, and will continue to grow with increasing consumer demand. By far, the matrix system is the most preferred delivery system in the nutraceutical industry for ER products. This technology offers a relatively simpler approach to manufacturing, involving the direct compression of blended actives and inactive materials in a solid dosage form, where the active is embedded in the matrix of rate-limiting materials. In some cases, depending on the nature of the materials, a granulation step may be necessary prior to compression. Naeem Shaikh, Ph.D., leads the formulation team and drives the research that helps inspire and propel the product momentum at National Enzyme Co. ( As an accomplished and published scientist, Shaikh leverages 28 years of experience, with previous research ranging from microencapsulation to release methods for solid and liquid dosa ge forms. Contract Manufacturing: Alternative Delivery Systems ON DEMAND DIGITAL SUMMIT Technology and Transparency in Supply Chain Sourcing WATCH NOW Sourcing ingredients is a critical topic for own-brand and contract manufacturers in the dietary supplement and natural products industry. Finding and evaluating suppliers and ingredients is complicated, ineffi cient and expensive. Watch this Digital Summit to learn how, the world's only factory-direct online nutritional ingredient marketplace, is enabling thousands of people like you to address these challenges and save both time and money. Sponsored by For a list of references, email

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