Natural Products Insider

SEP-OCT 2017

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116 INSIDER September/October 2017 SupplySide West The essence or central point of an idea is often called the "heart" of the matter. Yet, among supplement categories, heart health is often forgotten about. This may come at the expense of our collective interest to live longer, healthier lives. The job of the heart is to pump blood throughout the body, sending oxygen and nutrients to the rest of the body, and removing waste products. The heart pumps through the circulatory system, which has about 100,000 miles of blood vessels. 1 Heart disease is still the No. 1 killer in the United States, and when the heart is compromised, so often is the rest of the body. Dietary antioxidants are strongly linked to reductions in cardiovascular disease (CVD) risk. An abundance of evidence on the impact of antioxidant and nutrient intake on mortality from CVD has been published in recent years as a result of the National Health and Nutrition Survey (NHANES). For example, a lower intake of vitamins D and E was recently associated with high blood pressure, which is a major risk factor for CVD. 2 In a 2016 study published in the journal Circulation, intake of at least 16 g/d of whole grains was associated with a lower mortality rate from CVD. 3 But heart health doesn't always have to taste like cardboard. For example, consumption of three to four servings of antioxidant-rich chocolate per week was associated with a 10 percent lower rate of heart attack in Swedes. 4 Polyphenols and fl avonoids are the most abundant antioxidants in our diets. They are created by plants to protect them from oxidative stress, and they benefi t the human body in similar ways. Polyphenols also exhibit strong anti-infl ammatory activities that support a heart-healthy diet. For example, a reduction in anti- infl ammatory cytokines by polyphenols leads to reduced levels of atherosclerosis and blood lipids (especially "bad" low- density lipoprotein [LDL] cholesterol). Polyphenols also increase levels of protective markers, such as endothelial nitric oxide (NO), which helps blood vessels maintain their fl exibility. The typical, often-found result from consumption of polyphenol-rich fruits and vegetables is a reduction in CVD markers. 5 Infl ammation is more central to heart health than many previously thought. More recently, several studies have been published on the negative impact of a pro-infl ammatory diet, which can be measured by the Dietary Infl ammation Index (DII). 6 The Mediterranean diet, rich in fi sh, nuts and plant fats, is a prime example of a low-DII diet. Study after study supports the benefi ts of a low-DII diet on a number of endpoints, including reduced mortality from cardiovascular and brain ischemic events (heart attack and stroke), in addition to longer telomeres—chromosomal indicators of our biological age. 7 But when we think of the Mediterranean diet, many picture a nonagenarian drinking a glass of Chianti while slurping sardines from a can. But heart health and longevity isn't just for old Italians anymore. Athletes and active people of all ages appear to benefi t from heart-healthy diets. Low- carbohydrate, plant-based whole foods are key to maintaining optimal cardiovascular health. Getting more protein from plants instead of red meat has also been mentioned as a prime tipping point toward better cardiovascular health for the entire population. 8 Metabolic syndrome, which includes diabetes, obesity, CVD and other associated diseases, is a big problem for children in America. Part of the benefi t of plant-based diets for cardiovascular health (aside from the lower sugar, lower carb, higher antioxidants and better fats) is the quality of protein. Several new protein sources are emerging as "better-for-you" and more sustainable, such as hemp and pumpkin seed. Yet cow's milk protein is still thought to be a superior protein, since it is more like breast milk than a soybean or an almond. As new science emerges on heart- healthy ingredients, we can develop smarter, better products. Essentially, good, hard science will serve at the "heart" of our knowledge on cardiovascular health. Blake Ebersole has led a number of botanical quality initiatives and formed collaborations with dozens of universities and research centers. As president of NaturPro Scientifi c (npscientifi c.com), Ebersole established quality compliance and product development services for supplements and ingredients such as ID Verifi ed™. Follow him on Twitter at @NaturalBlake. Emerging Heart Health Ingredient Research by Blake Ebersole Learn more about heart health nutrient research from Blake Ebersole during the "Nutrition for Heart Health" Workshop on Friday, Sept. 29 at 8:30 a.m. at SupplySide West in Las Vegas. This session is underwritten by Nicolas Hall and Companies, Japan Bio Sciences Lab and Natec. supplysideshow.com Scan Here Heart Health Ingredients at SupplySide West Hear Blake Ebersole preview his presentation b y listening to SupplySide West Podcast 36: Nutrients for Heart Health and Beyond. For a list of references, email references@naturalproductsINSIDER.com

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