Natural Products Insider

MAR-APR 2018

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12 INSIDER March/April 2018 12 INSIDER March/April 2018 Several studies evaluating the effi cacy of probiotics in different areas of health and application have been published in recent years. Current research on probiotics indicates innovative trends in the areas of cognition, maternal and infant nutrition, and immune support via "inactive" strains, among others. Brain Health/Mood/Cognition The term "psychobiotics," according to Mal Evans, Ph.D., scientifi c director, KGK Science, was coined in 2013 by John F. Cryan, Ph.D., to describe an emerging branch of probiotic research with psychological implications. "Psychobiotics are bacteria that harness the gut-brain axis to infl uence stress, mood, anxiety and cognition," she said. "The possibility of infl uencing brain and behavior, without the toxicity profi le of traditional psychiatric interventions, has attracted growing research interest in the fi eld of probiotics." Bifi dobacterium longum 1714 (from Alimentary Health) was shown to reduce stress levels and improve memory in healthy volunteers, consistent with the promising preclinical fi ndings for this strain. 1 Early intervention with probiotic Lactobacillus rhamnosus GG may benefi t cognitive health in later years. A 2015 publication showed supplementation with Lactobacillus rhamnosus GG in infants during the fi rst six months of life reduced the risk of neuropsychiatric disorders later in childhood. At age 13, six out of 35 (17.1 percent) children in the control group were diagnosed with attention defi cit hyperactivity disorder (ADHD) or Asperger's syndrome, while no child in the probiotic group developed ADHD or Asperger's. 2 Maternal/Infant Nutrition A study published in 2017 aimed to evaluate the effect of Lactobacillus rhamnosus HN001 (from DuPont Nutrition & Health) during pregnancy and postpartum on symptoms of maternal depression and anxiety in the postpartum period. 3 This was a secondary outcome; the primary outcome was eczema in the offspring at 12 months of age. For the study, 423 women were randomized to placebo or HN001 starting at 14 to 16 weeks gestation until six months postpartum. Results showed mothers in the probiotic treatment group reported signifi cantly lower depression scores and anxiety scores than those in the placebo group. In a 2017 publication, oral administration of Lactobacillus fermentum CECT5716 (from Biosearch Life's Hereditum ® line) for 16 weeks in women who received a preventive dose of antibiotic in the context of delivery led to fewer instances of mastitis compared to placebo. 4 Sixteen women in the probiotic group developed mastitis versus 30 women in the control group. Therefore, the oral administration of L. fermentum CECT5716 during lactation decreased by 51 percent the incidence rate of clinical mastitis. The probiotic strain has also been shown to reduce the incidence of gastrointestinal (GI) and respiratory infections in infants, 5 and has been proven well-tolerated and safe in infants ages 1 to 6 months. 6 Prenatal nutrition and infant health are key areas of interest for researchers. Bérengère Feuz, marketing manager at Lallemand Health Solutions, pointed to the ongoing trial "The Effect of Probiotics on Maintenance of Health in Pregnancy and Infants," supporting her company's interest in the topic. Ideal for supporting women of childbearing age at risk of iron defi ciency, Probi FerroSorb ® by Viva 5 Corp. is a combination of Lactobacillus plantarum 299v (LP299V ® ), vitamin C, folic acid and iron—designed to increase iron absorption while maintaining digestive health without the constipation sometimes experienced with iron supplementation programs. Immunity A meta-analysis of four studies showed Lactobacillus rhamnosus GG may reduce episodes of ear and upper respiratory tract infections in healthy children. 7 Lactobacillus casei DN0114 001 was effective in reducing incidence and duration of common infectious disease in a study of 638 young children 8 and another study of stressed adults. 9 In a double-blind study, a proprietary blend of the probiotics of Bifi dobacterium lactis Bi-07™ and Lactobacillus acidophilus The impact of probiotics on prenatal nutrition is an area of interest for researchers. A recent study found a probiotic strain could help with digestion of plant proteins. "Inactive" probiotics are increasingly studied for their benefits to immune health. Probiotic Trends in Research, Innovation by Rachel Adams INSIDER's Take Supplements: Probiotics Current research on probiotics indicates innovative trends in the areas of cognition, maternal and infant nutrition, and immune support.

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