Natural Products Insider

MAR-APR 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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14 INSIDER March/April 2018 NCFM ® (HOWARU ® Protect Kids, from DuPont Nutrition & Health) supported respiratory health with symptom duration shortened from 6.5 to 3.5 days, a decrease in incidences of respiratory symptoms, an 80 percent reduction in antibiotic use and a reduction in the number of sick days by almost half compared to placebo. 10 In seniors, daily intake of Bifi dobacterium lactis HN019™ (HOWARU ® Protect Senior, from DuPont Nutrition & Health) by healthy, elderly adults showed B. lactis HN019™ enhanced cellular immune activity. 11 All doses of the probiotic increased Bifi dobacterium population signifi cantly during intervention, when compared to pre-intervention levels. In the same study, potentially harmful bacteria (enterobacteria) decreased signifi cantly in high- and medium-dose groups. Results of a randomized, double-blind, placebo-controlled trial evaluated the impact of probiotic strain Lactobacillus coryniformis K8 CECT5711 (from Biosearch Life) on immune response to the infl uenza vaccine and assessed the effects on symptoms related to respiratory infections. For the study, 98 nursing home residents over the age of 65 years were randomly assigned to receive L. coryniformis K8 CECT5711 (3 × 109 CFU/d) or a placebo for two weeks before infl uenza vaccination. 12 The primary outcome was the percentage of seroconversion. The secondary outcomes were the incidence of infl uenza-like illness (ILI) and respiratory symptoms associated with respiratory infections during the fi ve-month follow-up period. The serum cytokine and immunoglobulin levels were also evaluated. Results showed the percentage of responders to the vaccination was higher in the probiotic group than in the control group. Ingestion of L. coryniformis was associated with a signifi cantly lower incidence of respiratory symptoms commonly associated with respiratory infections and lower consumption of analgesics. Probiotics are defi ned as live organisms that benefi t human health. These bacteria proliferate in the gut and pump out benefi cial metabolites and other byproducts. "However, in recent years, dead microbes have been also shown to exhibit benefi cial effects that are equivalent to, or even greater than, live microbes," said Yoshitaka Hirose, Ph.D., group manager, House Wellness Foods, dubbing these inactive bacteria "immunobiotics. They are defi ned as the microbe which promotes [the] immune system through activation of gut immunity, and thus include dead microbes." Heat-killed Lactobacillus plantarum L-137 (HK L-137), an immunobiotic strain isolated from fermented food, induces interleukin 12 (IL-12) or type I interferon (IFN), which lead to a T helper (Th) 1 type immune response and subsequent antiallergic, antitumor or antiviral effects in mouse models, he explained. 13,14,15 Further, oral intake of HK L-137 has been shown to increase Th1-related immune functions, health-related quality of life and production of type I IFN, and decrease the incidence The system of natural, proven ingredients that finds another level. Give your products the edge at Ay uric The system of natural, proven Ay uric ingredients that finds another level. Give your products the edge at Supplements: Probiotics

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