Natural Products Insider

MAR-APR 2018

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18 INSIDER March/April 2018 A 2017 publication evaluated the effects of co-administration of Bacillus coagulans GBI-30, 6086 (GanedenBC 30 ) with β-hydroxy-β-methylbutyrate (HMB) calcium (CaHMB) to CaHMB alone on infl ammatory response and muscle integrity during 40 days of intense military training. 23 Results supported HMB supplementation to attenuate the infl ammatory response to intense training, and found the combination of BC 30 with CaHMB may be more benefi cial than CaHMB alone in maintaining muscle integrity during intense military training. A combination of Bifidobacterium lactis Bi-07 ® and Lactobacillus acidophilus NCFM ® (HOWARU ® Protect Sport, from DuPont Nutrition & Health) consumed daily over a fi ve-month period was shown to reduce risk of an upper respiratory illness and delay time to respiratory tract illness compared to placebo in physically active adults. The study showed signifi cantly extended exercise duration and signifi cantly improved training duration. 24 Food Allergies "The prevalence of allergic diseases has been dramatically rising in the United States and other developed nations over recent decades," said Ralf Jäger, scientifi c advisor at Pharmachem Labs, a division of Ashland. "Growing evidence suggests a partial role for the microbiome in the development of these allergic diseases." Among the earliest and most common food allergic diseases of infancy, per Jäger, is intolerance or allergy to cow's milk protein, "yet its pathophysiology is not well understood." Administration of probiotic Lactobacillus rhamnosus GG resolved symptoms of four clinically diagnosed cases quickly and completely, with the range of time from probiotic initiation to symptom resolution between seven and 28 days, according to a 2016 publication. 25 The probiotic, when administered to infants with cow's milk allergy, in combination with extensively hydrolyzed casein for six months, led to the development of tolerance to cow's milk in 42 percent of infants who received the probiotic/casein combination, compared to zero who received casein only, when tested via an oral food challenge 12 months after treatment. 26 "Most tolerant infants showed a signifi cant increase in fecal butyrate levels," Jäger said. "L. rhamnosus GG promotes tolerance in infants with cow's milk allergy by infl uencing the bacterial community structure of the infant gut." Looking to the impact of probiotics on Celiac disease and gluten intolerance, B. breve BR03 showed a positive effect on decreasing the production of pro-infl ammatory cytokine tumor necrosis factor (TNF)-alpha in children (10.4 ± 4.2 years) with Celiac disease, consuming a gluten-free diet. 27 Gut Health Gut and digestive health continue to be top areas of research for probiotics, including a recent study showing the benefi ts of probiotics on protein digestion. In a randomized, placebo-controlled, parallel group study, supplementation with one tablet of Sabinsa's LactoSpore ® (each tablet containing 2×109 cfu Bacillus coagulans MTCC 5856) per day for 90 days, in addition to standard treatment, resulted in a signifi cant decrease (P<0.01) in the clinical symptoms of diarrhea- predominant irritable bowel syndrome (IBS) such as bloating, vomiting, diarrhea, abdominal pain and stool frequency when compared to placebo group. 28 Additionally, the LactoSpore group showed decreased disease severity based on physician's global assessment and better IBS-quality of life compared to placebo. In a 2017 publication, supplementation with Bacillus subtilis (as DE111) led to a healthier bowel index as measured by the Bristol Stool Chart scale. 29 For the study, 50 people were evaluated by their stool profi le, food diary and questionnaire while taking the probiotic or placebo daily for 105 days. Researchers concluded DE111 supported regularity by improving occasional constipation and/or diarrhea in healthy individuals. Bifi dobacterium lactis is another strain supporting healthy bowel movements. A Chinese study found that women who consumed yogurt containing Bifi dobacterium lactis DN-173 010 averaged 1.5 more bowel movements than the placebo group. 30 A 2015 meta-analysis of 21 randomized controlled trials concluded Saccharomyces boulardii yeast reduced the risk of antibiotic-associated diarrhea. 31 In a recent publication, the effects of probiotics on digestion of plant proteins was evaluated. For the study, three plant proteins, from pea, soy and rice, were digested in an in vitro model of the stomach and small intestine in the absence and presence of GanedenBC 30 . 32 Results showed enhanced protein digestion by BC 30 by dual benefi t: enhanced amino acid bioavailability from plant proteins in the upper GI tract and a healthier environment in the colon. Supplements: Probiotics For a list of references, email references@naturalproductsINSIDER.com Gut and digestive health continue to be top areas of research for probiotics, including a recent study showing the benefits of probiotics on protein digestion. Probiotics Market Trends Digital Magazine LEARN MORE about probiotics market trends, along with strategies on how to effectively communicate the benefi ts of probiotics products, by downloading the Probiotics Market Trends and Messaging Digital Magazine. Vol. 7, No. 15 July 2017 naturalproductsinsider.com US$20.75 Probiotics Market Trends and Messaging west.supplysideshow.com SEPTEMBER 25-29 Expo Hall September 27 & 28 Mandalay Bay Las Vegas Scan Here

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