Natural Products Insider

MAR-APR 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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Nevertheless, lifestyle changes are not suffi cient in many cases, so medications such as statins are required. While usually effective, drugs are not exempt from adverse side effects, especially after long-term treatments, so complementary approaches to heart health are in high demand from the industry, clinicians and the public. Probiotics are increasingly emerging as a strategy, thanks to the tremendous advances being made in microbiome research. A growing body of evidence suggests food microbes can have a benefi cial impact on blood lipid levels and blood pressure, with studies showing at least some probiotic strains can impact all the main biomarkers of CVD risk at once. 3 This is an enormous advantage over non-probiotic functional food ingredients and drugs, which tend to have narrow therapeutic targets and therefore deliver more specifi c physiological effects. As live, metabolically active organisms, probiotics can harbor complex and diverse mechanisms of action for a natural, holistic and non-pharmaceutical approach to cardiovascular health. How Does This Work? Approximately one-third of the cholesterol absorbed through the intestine comes from food, and gut microbes are sometimes exposed to it in advance of intestinal cells. Microbes can reduce the absorption of dietary cholesterol in three main ways. First, some cholesterol is absorbed into the surface of intestinal bacteria. 4 Second, some bacteria can break down and assimilate cholesterol for nutrition. Third, some microorganisms can transform cholesterol into a chemical called coprostanol, which cannot be absorbed and is thus excreted, lowering the body's cholesterol levels. 5 Probiotics stimulate microbial growth, supporting their benefi cial activities. By modulating the human microbiome activity with probiotic support, science is increasingly able to demonstrate the potential to reduce cholesterol and blood pressure. As more is learned about the role of the gut microbiome in cardiovascular health and disease, probiotics with specifi c and complex mechanisms of action will increasingly become fi rm candidates to aid in the prevention and management of CVD. When it comes to hypertension, probiotic-fermented foods have shown promising results in blood pressure reduction thanks to their chemical content. 6 However, recently selected probiotic strains have also been found to lower blood pressure without previous fermentation processes. 7 There is, therefore, great scope for making the benefi ts of microbiome modulation available to wider markets. Luis Gosalbez is the director of business development at Opt iBiotix Health Plc. ( in the U.K. Previously, he held different positions in the biotechnology industry and in pharmaceutical consulting in Spain and Germany. BOOK YOUR STAY AT EAST.SUPPLYSIDESHOW.COM Secaucus, NJ Meadowlands Exposition Center April 10-11, 2018 SECURED YOUR HOTEL? LIMITED ROOMS LEFT IN THE SUPPLYSIDE EAST ROOM BLOCK. *LIMITED AVAILABILITY AFTER MARCH 9TH Supplements: Probiotics For a list of references, email

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