Natural Products Insider

MAY-JUN 2018

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naturalproductsinsider . com 11 Antigen-specifi c IgY products have been shown to be effective in promoting gut function and immunity in humans, 4 as well as in reducing the side effects of dysbiosis. 5 IgY Max is a polyvalent, antigen-specifi c IgY product targeting 26 of the most common human-relevant pathogens. Native lactoferrin from cow's milk (as Proferrin ® , from Ingredia) has been shown via internal, unpublished research to support gut health by renewing epithelial cells (growth and differentiation), an important barrier against infections. Additionally, internal research showed the ingredient's ability to reduce the release of tumor necrosis factor-alpha (TNF-alpha), a pro-infl ammatory marker. Still buzzing with interest from co nsumers are probiotics, which can benefi t immunity via impact on the gut microbiome. "Over the past 15 to 20 years, research has shown the effects of certain probiotics at different levels," said Bérengère Feuz, marketing manager, Lallemand Health Solutions: 1 Through a barrier effect, probiotics help protect the gut surface from potential pathogens and prevent their translocation from the gut lumen; 2 By modulating the nonspecifi c innate immune response; and 3 By activating the specifi c adaptive immune response. Probiotics act as a fi rst line of defense, Feuz explained. "By enhancing the natural gut microbiota, probiotics can help keep pathogens at bay through several actions, such as competitive exclusion." Feuz cited Lallemand's Lactobacillus helveticus Rosell ® -52's ability to bind to the attachment sites of pathogenic bacteria, such as enteropathogenic E. coli on intestinal epithelial cells, as an example. Probiotics have also been shown to improve the intestinal barrier function and enhance epithelium permeability and integrity, or enhance mucus production, Feuz added. Recent research expanded the potential of probiotics to impact immunity. According to a 2017 publication, certain probiotic strains infl uenced both innate and acquired immune response at the gene expression level. 6 The study used human expression microarray chips in an in vitro intestinal epithelial cell model to determine the impact of the strains on toll-like receptor 3 (TLR3)-mediated infl ammation. "These mechanistic data are important, but they need to be validated by clinical studies," Feuz said. Looking to individual strains, a clinical study investigated the benefi ts of individual probiotic strains on the occurrence of common infections (cold and fl u) in stressed subjects more prone to infections, and concluded a benefi cial effect of the Bifi dobacterium bifi dum R0071 strain (reduction of the num ber of sick days). 7 Cazzola et al. showed children's diets supplemented with a synbiotic formula (Bifi dobacterium bifi dum Rosell ® -71, Bifi dobacterium infantis Rosell ® -33, Lactobacillus helveticus Rosell-52 and fructooligosaccharides [FOS]) for three months decreased the risk of occurrence of common infections by 25 percent vs. placebo. Other studies confi rmed the synbiotic effects on children's immunity, in particular through positive effect on immunosurveillance, like increased Immunoglobulin A (IgA) expression in children with low IgA levels. 8,9 An internal, unpublished study showed benefi ts of another strain (Lactobacillus helveticus LAFTI ® L10, from Lallemand) to support the immune response in stressed subjects. Three hundred students who normally suffer from at least two colds a year were included in the 10-week study. The study showed a signifi cant reduction of the number of systemic symptoms by 12.2 percent in the probiotic group; moreover, the symptoms were less severe with the probiotic. As a result, the probiotic signifi cantly reduced the need for medication: the total number of days with Supplements: Immune Health Grain sizes shown at 100% Discover a Better Salt Supplier The Worldwide Leader In - E S T A B L I S H E D 2 0 0 1 - HIMALAYAN PINK SALT HIMALAYAN PINK SALT HIMALAYAN PINK SALT SaltWorks® produces the best all-natural Himalayan Pink Salt. With the industry's most stringent safety standards, advanced salt processing technology and large volume capabilities, SaltWorks Ancient Ocean® is the cleanest, safest and highest quality available. Guaranteed. LEVEL 2 | EXCELLENT RATING 800-353-7258 | info@seasalt.com www.seasalt.com Products with "immune system" positioning accounted for 11.3 percent market share of supplements globally and were valued at close to US$2 billion total in 2015, with a compound annual growth rate (CAGR) of 10.7 percent from 2011 to 2015.

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