Natural Products Insider

MAY-JUN 2018

INSIDER is the leading information source for marketers, manufacturers and formulators of dietary supplements, healthy foods and cosmeceuticals. Since 1997, INSIDER has been serving the needs of the global nutrition industry.

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12 INSIDER May/June 2018 medication intake (mainly analgesics) was reduced by 23 percent. The same strain also recently showed benefi ts for training athletes in a randomized study. 10 Results of a randomized, double-blind, placebo-controlled trial sought to evaluate the impact of probiotic strain Lactobacillus coryniformis K8 CECT5711 (from Biosearch Life) on immune response to the infl uenza vaccine and to assess effects on symptoms related to respiratory infections in 98 nursing home residents over age 65. 11 The administration of the probiotic during the two weeks prior to an infl uenza vaccination signifi cantly increased the percentage of responders to the vaccine. The probiotic treatment also reduced the incidence of symptoms related to respiratory infections suffered during the fi ve months after probiotic treatment, and resulted in 86 percent lower consumption of analgesics in the elderly group who received the probiotic strain. In a double-blind study, a proprietary blend of probiotics (HOWARU ® Protect Kids, from DuPont Nutrition & Health) supported respiratory health with symptom duration shortened from 6.5 to 3.5 days, a decrease in incidences of respiratory symptoms, an 80 percent reduction in antibiotic use and a reduction in the number of sick days by almost half, compared to placebo. 12 In seniors, daily intake of Bifi dobacterium lactis HN019™ (as HOWARU ® Protect Senior, from DuPont Nutrition & Health) by healthy, elderly adults showed B. lactis HN019 enhanced cellular immune activity. 13 All doses of the probiotic increased Bifi dobacterium population signifi cantly during intervention, when compared to pre-intervention levels. In the same study, potentially harmful bacteria (enterobacteria) decreased signifi cantly in high- and medium-dose groups. A combination of Bifi dobacterium la ctis Bi-07 ® and Lactobacillus acidophilus NCFM ® (as HOWARU ® Protect Sport, from DuPont Nutrition & Health) consumed daily over a fi ve-month period was shown to reduce the risk of an upper respiratory illness and delay time to respiratory tract illness compared to placebo in physically active adults. The study showed signifi cantly extended exercise duration and signifi cantly improved training duration. 14 A probiotic strain of Streptococcus salivarius (as BLIS K12™, from Stratum Nutrition), a species that is common in the mouths of healthy individuals, supports health several ways, one of which is immune modulation, said Nena Dockery, technical services manager at Stratum Nutrition. One study demonstrated S. salivarius K12's ability to stimulate an anti-infl ammatory response that protected the oral cavity from infl ammation and apoptosis induced by pathogens. 15 In another study, K12 was shown to promote the production of interferon gamma (IFN-γ), an immune system protein (cytokine) that is known to contribute to nonspecifi c immunity against many intracellular bacteria and viruses. 16 A probiotic strain of Bacillus coagulans (as Bacillus coagulans GBI-30, 6086, from GanedenBC 30 ) offers immune-boosting properties. In a controlled study of 10 participants, 30 days of supplementation with the probiotic strain increased T cell production of TNF-alpha in participants after exposure to adenovirus and infl uenza A. 17 Building on these results, researchers evaluated the effect of GanedenBC 30 on immunological marker levels following viral exposure, and found a statistically signifi cant difference in interleukin-8 (IL-8) levels after infl uenza A exposure, along with IFN-y levels after adenovirus exposure. 18 "In recent years, dead microbes have been also shown to exhibit benefi cial effects that are equivalent to, or even greater than, live microbes," said Yoshitaka Hirose, Ph.D., group manager, House Wellness Foods. Heat-killed Lactobacillus plantarum L-137 (HK L-137), an immunobiotic strain isolated from fermented food, induces IL-12 or type I interferon (IFN), which lead to a T helper (Th) 1 type immune response and subsequent antiallergic, antitumor or antiviral effects in mouse models, Hirose explained. 19,20,21 Further, oral intake of HK L-137 increased Th1-related immune functions, health-related quality of life and production of type 1 IFN, and decreased the incidence of upper respiratory tract infection (URTI) in healthy subjects. 22,23,24 Absorbed by specialized immune tissue in the gut, a proprietary baker's yeast beta 1,3/1,6 glucan (as Wellmune ® , from Kerry) binds to neutrophils, enabling them to move more quickly to recognize and kill foreign challenges. These effects are documented in several studies in a range of populations. In a clinical study of children in a daycare setting, Wellmune decreased episodes of common childhood illnesses and symptoms of illness, with 62 percent of children taking the ingredient reported as having "good" health versus 15 percent of children who did not consume Wellmune. 25 In high-stress populations, Wellmune signifi cantly reduced URTI symptoms in a clinical study of medical students; 26 signifi cantly decreased URTI symptoms while increasing vigor by 26 percent and improving well-being by 8.3 percent in Supplements: Immune Health Immune Health Digital Magazine Read more about ingredients to support immunity by downloading INSIDER's "Ingredients to Boost Immunity" Digital Magazine. Vol. 7, No. 26 November 2017 US$20.75 Secaucus, NJ Meadowlands Exposition Center APRIL 10 & 11 2018 Ingredients to Boost Immunity Scan Here ents-boost-immunity "In recent years, dead microbes have been also shown to exhibit beneficial effects that are equivalent to, or even greater than, live microbes." Ñ Yoshitaka Hirose, Ph.D., group manager, House Wellness Foods

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