Natural Products Insider

MAY-JUN 2018

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14 INSIDER May/June 2018 stressed women; 27 reduced the number of individuals reporting URTI symptoms in stressed adults by 71 percent while decreasing fatigue and increasing vigor; 28 and reduced URTI symptoms while improving overall physical health in a two-week trial of Montana's Wildland Firefi ghters. 29 Supporting athletes, Wellmune supplementation by marathon runners led to a 40 percent reduction in URTI symptoms, 30 while Wellmune decreased risk of immune system suppression in both recreational and elite athletes. 31,32 It also increased vigor and mental clarity while reducing fatigue, tension, confusion and URTI symptoms in marathon runners. 33 Beta-glucan from algae shares a common backbone of 1,3 linkages, "which act as immunomodulators because the human body recognizes it as 'non-self' or foreign," explained Emily Pankow Fritz, Ph.D., technical services manager, Active Wellness, and Chris Sadewasser, technical service associate, Human Nutrition and Health, Kemin. "Non-self" substances are referred to as pathogen-associated molecular patterns (PAMPs) detected by specialized surface receptors of immune cells. 34,35,36 Through binding and engulfi ng beta-glucan, these specialized cell surface receptors induce signaling cascades that prime immune cells, Pankow Fritz and Sadewasser said. 37,38,39,40 Unpublished, in vitro studies of ingredients derived from Euglena gracilis fermentate powder (BetaVia Complete [containing more than 50 percent algae beta-glucan] and BetaVia Pure [containing more than 95 percent algae beta-glucan], from Kemin) showed similarities to the Acid Resistant Vegetable Capsules ) ' u n . , u, ' . ' AN EXCELLENT CHOICE FOR DELIVERY OF ACID-SENSITIVE ACTIVE INGREDIENDTS . . . <> . BioCaps Enterprises, Inc. www.biocaps.net • info@biocaps.net US Patent 9452141 activity of yeast-derived, immune-support ingredients. "BetaVia Pure and BetaVia Complete are recognized by cell surface receptors of key immune cells including macrophages and dendritic cells," Pankow Fritz and Sadewasser said. "After being recognized by immune cells, BetaVia ingredients are phagocytosed and absorbed, resulting in cytokine and chemokine signaling that primes the immune system." Research supporting the effi cacy of beta glucan, available along with in vitro data, supports that the beta (1,3) glucan in BetaVia Complete and BetaVia Pure can act as immunomodulators, Pankow Fritz and Sadewasser said. Sulforaphane, the active component of broccoli sprout powder, increased the activity of Phase 2 enzymes that inactivate harmful chemicals and reinforce the body's natural responses to oxidative stress. 41 BroccoPhane ® broccoli sprout powder from Bioriginal is standardized to contain a minimum of 4,000 ppm of sulforaphane. Glucosinolates, an antioxidant found in mature broccoli plants, enhanced the activity of liver and intestinal enzymes essential to the detoxifi cation of potentially harmful chemicals and byproducts. 42 Bioriginal's BroccoSinolate 2.0 ® is standardized to 4 percent glucosinolates. Glutathione is an antioxidant found naturally in nearly every cell of the body. Kyowa Hakko's Setria ® glutathione, made from a patented fermentation process, supports proper function of white blood cells, including T cell, stimulates the natural ability of some immune cells and can regenerate other antioxidants, such as vitamins C and E. 43 Supplementation with the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can change composition of immune cells, said Mal Evans, Ph.D., scientifi c director at KGK Science, "which in turn can have effects on phagocytosis, T cell signaling and antigen presentation capability." 44 Beyond specialty nutrients, maintaining adequate levels of vitamins and minerals is critical to keeping the immune system strong. "Sometimes, people don't remember that regular vitamins and minerals can really help their immunity," said Karen Dhanraj, technical marketing and sales manager, Lallemand Bio- Ingredients. (Stauber is the exclusive U.S. distributor of Lallemand's nutraceutical line.) "For example, vitamin D can modulate the innate and adaptive immune systems, and cells of the immune system have been shown to respond to vitamin D." 45,46 Other critical nutrients include selenium, which exerts effects on infl ammation and immune responses; 47,48 vitamins B6 and B12, which have been shown to positively affect white blood cell counts; 49,50 copper, which is essential against immune defense, especially against bacterial infections; 51 and zinc. Zinc-defi cient patients have been shown to have severe immune dysfunctions, Dhanraj explained. 52 For a list of references, email references@naturalproductsinsider.com Supplements: Immune Health

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