Natural Products Insider

MAY-JUN 2018

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6 ASHWAGANDHA ADVANTAGE Exploring the Ashwagandha Advantage Ashwagandha and Longevity THEORY: Several Ayurvedic botanicals are men� oned in ancient texts as serving as rasayanas or life extenders. Extract of ashwagandha (Withania somnifera Dunal) root is among the leading ingredients used for this purpose, and it has shown posi� ve eff ects against stress and infl amma� on. Inves� gators have proven the usefulness of the CaenorhabdiƟ s elegans worm model in lifespan extension research. Could consump� on of ashwagandha root extract and the purifi ed components in it posi� vely aff ect lifespan? PARAMETERS: Wild type C. elegans or mutant worms were grown on NGM plates with OP50 E. coli as food, with ashwagandha root extract (ARE) or purifi ed ingredients (PI) (both provided by Ixoreal Biomed) on the plates. ARE was diluted into various frac� ons: suspension, ~80% water soluble frac� on, ~60% water soluble frac� on, and ethanol solubilized mixture of the purifi ed components in the same ra� o as ARE. Treatment was chronic from embryo stage to death, and both lifespan and dose response assays were conducted. Source: Kumar R et al. "Withania somnifera root extract extends lifespan of CaenorhabdiƟ s elegans." Annals Neurosci. 2013;20(1):13-16. DOI: 10.5214/ans.0972.7531.200106. IMPACT: Around the world, people are living longer lives, as access to health care, sanita� on and quality food have improved health and lifespan. A new study out of Imperial College London es� mated that average lifespan by 2030 could extend beyond age 90 in many developed countries, par� cularly those with universal health coverage. 1 However, beyond just length of life is suppor� ng health of life; the integrated use of an ingredient such as ashwagandha that has proven health benefi ts in stress management and infl amma� on could ensure the addi� onal years are healthy ones. 1. KonƟ s V et al. Lancet. 2017; ePub 21 February. DOI: 10.1016/S0140-6736(16)32381-9 Source: Infographic brought to you by OUTCOME: Researchers concluded: "We are able to show that one of the age-old healthy longlife supplements, Ashwagandha does extend lifespan of C. elegans. … It will be worthwhile to evaluate KSM-66 for longevity eff ects on higher animal model." Treatment with the purifi ed ingredients at a concentra� on of 100 ng/ml extended the lifespan in the human nico� nic acetylcholine receptor alpha-7 equivalent mutant, acr-16, but not wild type or other mutant worms. The purifi ed extract increased lifespan by 21.4% compared to control and 14% compared to ethanol.

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