Natural Products Insider

MAY-JUN 2018

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18 INSIDER May/June 2018 Two-thirds of cartilage is comprised of collagen. Cartilage ECM features type 2 collagen, which contains glycoproteins, proteoglycans and HA. Thus, type 2 collagen is an increasingly popular supplement ingredient for joint health, including in sports nutrition. A glycosylated, undenatured type 2 collagen ingredient derived from chicken sternum (as UC-II ® , from InterHealth/Lonza) improved joint function and pain in healthy, active adults with post-exercise joint pain, but no arthritis or joint pain at rest. 11 The trial found knee fl exion and extension improved in those taking UC-II for 120 days, compared to those taking placebo; the UC-II group also took longer to feel pain after exercise than baseline and placebo, and fi ve UC-II patients reported no post-exercise pain. Similar benefi ts were noted in research on a type 2 collagen derived from a hormone- and antibiotic-free chicken sternum ingredient (as BioCell Collagen ® , from BioCell Technology), which also contains GAGs such as chondroitin sulfate and HA. A 2012 study showed BioCell supplementation for 70 days in patients with progressive hip or knee OA helped manage symptoms, including pain measured by VAS and WOMAC scores, as well as improved physical activities, compared to placebo. 12 Researchers in another randomized, controlled trial found BioCell supplementation for six months improved knee OA symptoms, such as pain (as measured by WOMAC and VAS scores), compared to both placebo and a combination of glucosamine and chondroitin. 13 Collagen peptides supply amino acids—including glycine, proline and hydroxyproline—to stimulate and protect chondrocyte cells, and promote the synthesis of new cartilage ECM. 14,15 Six months of hydrolyzed type 1 collagen peptide (as Peptan ® , from Rousselot) reduced joint pain and increased joint mobility (per WOMAC and Lysholm knee pain scores) in patients with OA. 16 A 2017 study of collagen peptides (as FORTIGEL ® , from Gelita) involved athletic subjects with activity-related knee joint discomfort due to overloading or incorrect loading of the joint during physical activity. 17 Researchers found a statistically signifi cant improvement in activity-related pain intensity in the FORTIGEL group compared to placebo. A supplement combining FORTIGEL and fucoidan brown algae (as ACTEN ® , from Acten) reduced VAS scores for pain and Lequesne Functional Index (LFI) for severity of OA, similar to the comparison protocol combining glucosamine, chondroitin sulfate, HA and vitamin C (important for formation of connective tissue). 18 Bone morphogenetic proteins (BMPs) are growth factors that can stimulate cartilage growth. A protein complex containing BMPs and other growth factors (as Cyplexinol ® , from ZyCal Bioceuticals Inc.) taken by older adults (55 years and up) who had moderate-to- severe symptomatic OA hip or knee pain increased quality of life and decreased symptoms such as pain and stiffness (per WOMAC scores). 19 sales@siskfs.com • 410-754-8141 • www.siskfulfillment.com Dietary Supplement Warehousing & Order Fulfillment When you choose Sisk for your Dietary Supplement Fulfillment Program you get: Scan for more details & contact us today! Fulfillment Service Inc. SISK • an FDA REGISTERED FACILITY • NSF cGMP COMPLIANCE • TEMPERATURE & HUMIDITY CONTROL • RETURNS MANAGEMENT • HIGH VOLUME ORDER CAPACITY • SAME DAY ORDER FULFILLMENT • LOT # AND EXPIRATION DATE CONTROL Sports Nutrition: Joint Health

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