Natural Products Insider

JUL-AUG 2018

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6 INSIDER July/August 2018 According to the latest "The State of Aging and Health in America" report by the U.S. Centers for Disease Control and Prevention (CDC), longer life spans and the aging Baby Boomer demographic are the key factors contributing to growth of the aging population. The number of those ages 65 and above is expected to double by 2030 to amount to roughly 72 million, which is 20 percent of the total U.S. population. The United Nations predicted one in six people globally will be over age 60 by 2030, compared to one in eight people over age 60 in 2015. By 2050, the prediction rises to one in every fi ve people. As the body ages, its cells and communication systems become less balanced and effi cient, which leads to greater production of free radicals and increased signaling of infl ammatory cytokines and, thus, deterioration of cells and tissues. Tryggvi Stefánsson, science manager, Algalif, emphasized the relationship between aging, free radical production and health. "Younger people are naturally better protected from free radicals and other reactive oxygen species (ROS) through balanced activity of the mitochondria, effi cient antioxidant and DNA repair systems, and active protein degradation machinery," he said. "Aging, on the other hand, is generally accompanied by mitochondrial dysfunction leading to increased free radical production that, in turn, leads to an overloading of the defense systems and oxidative damage of cellular components." 1 Stefánsson noted several health concerns affecting seniors and mediated by oxidative stress and imbalances between pro- oxidants, such as ROS, and antioxidants, including oxidation of blood lipids (cholesterol and triglyceride), 2 pain and stiffness in joints, 3 cognitive decline, 4 age-related ocular diseases 5 and skin changes such as thinning of skin layers, loss of elasticity and function of oil glands, and accumulation of pigments. 6 Anti-aging ingredients—or "healthy aging" ingredients, as may be a more accurate term based on market trends—often target specifi c health concerns including heart health, brain health and cognition, bone and joint health, skin health and eye health. Healthy Hearts For the aging population, heart health is especially critical. The American Heart Association (AHA) estimated 15.9 million deaths caused by heart disease among those ages 70 and up—along with 11.4 million among those ages 30 to 69—could be delayed or prevented in 2025 if targets aimed at reducing salt intake and tobacco and alcohol use, managing obesity, and lowering blood pressure and glucose levels are met. A recent study by the Mayo Clinic found intake of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) omega-3s helped reduce risk of coronary heart disease (CHD), especially among people in higher risk populations, such as those with high low-density lipoprotein (LDL, or "bad") cholesterol. 7 Astaxanthin, which is generally commercially derived from Haematococcus pluvialis microalgae, is a potent antioxidant offering heart healthy effects, among other benefi ts. In healthy, postmenopausal women with high-levels of oxidative stress, natural astaxanthin (12 mg/d for eight weeks) signifi cantly decreased lower limb vascular resistance, a measure of functioning of the circulatory system. 8 Additionally, astaxanthin at doses of 12 and 18 mg/d signifi cantly reduced triglycerides, while 6 and 12 mg/d doses signifi cantly increased high-density lipoprotein (HDL, or "good") cholesterol in a randomized, placebo-controlled trial of 61 subjects with fasting serum triglyceride levels between 120 and 200 mg/dl. 9 A blend of tomato phytonutrients (as Lycomato™, from Lycored) supported cardiovascular health via supporting healthy circulation, 10 maintaining healthy blood pressure within normal range 11,12 and boosting the body's own protection mechanisms against oxidative stress, while reducing levels of clinically relevant biomarkers such as C-reactive protein (CRP)— commonly used to track cardiovascular condition. A standardized tomato nutrient complex (as Cardiomato™, from Lycored) reduced oxidized LDL cholesterol after two weeks of supplementation in a double- blind, placebo-controlled study of 150 healthy subjects. 13 A meta-analysis of seven randomized, controlled trials published in 2017 indicated the potential of the botanicals turmeric and curcumin to improve serum lipid levels in patients at risk of cardiovascular disease (CVD). 14 Specifi cally, research showed the ability of turmeric and curcumin to lower triglycerides and LDL cholesterol, though no effect on HDL cholesterol was seen. Vitamin K2 has become a rising star in the heart health arena, especially for women in later stages of life. Vitamin K2 (as MenaQ7 ® , from NattoPharma) improved arterial stiffness in 244 healthy, postmenopausal women administered 180 µg of MenaQ7/d for three years. 15 Arterial stiffness is a concern for women supplementing with calcium, which can lead to calcifi cation and hardening of the arteries, known as atherosclerosis. Also supporting women, French maritime pine bark extract (as as Pycnogenol ® , from Horphag Research) One in six people globally will be over age 60 by 2030, compared to one in eight people over age 60 in 2015. Anti-aging ingredients target specific health concerns related to the heart health, brain and cognition, bones/joints and skin. Simplified supplement regimens and easy-to-swallow delivery formats may appeal to aging consumers facing pill fatigue. Developing Supplements to Support Healthy Aging by Rachel Adams INSIDER's Take Supplements: Healthy Aging while 6 and 12 mg/d doses signifi cantly increased high-density lipoprotein (HDL, placebo-controlled trial of 61 subjects with Pycnogenol ® , from Horphag Research)

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