Natural Products Insider

JUL-AUG 2018

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naturalproductsinsider.com/ashwagandha-advantage 7 ksm66ashwagandhaa.com Source: Infographic brought to you by Ashwagandha Supports Common Consumer Challenges Chronic stress has been linked to weight gain. This infographic reviews clinical research using ashwagandha root extract to mi� gate the stress-weight connec� on by infl uencing levels of the stress hormone cor� sol. naturalproductsinsider.com/ashwagandha/ infographic-ashwagandha-and-stressweight- management-connection-0 DOWNLOAD To View full infographics naturalproductsinsider.com/ashwagandha/ infographic-ashwagandha-improves-memory- cognitive-function-0 DOWNLOAD To View full infographics Ashwagandha has been used for brain support, but clinical research is s� ll needed to outline its eff ect on diff erent aspects of cogni� ve func� on. THEORY: One of the central herbs in Ayurveda, root extract of ashwagandha (Withania somnifera Dunal) has been used for its neuroprotec� ve, an� -stress and rejuvena� ve eff ects, connected to its interplay with mul� ple systems in the body, including the nervous system, endocrine system and energy produc� on system. While it has been used for brain support, clinical research is s� ll needed to outline its eff ect on memory improvement and diff erent aspects of cogni� ve func� on. This study sought to explore ashwagandha's impact on memory, visuo-spa� al processing, execu� ve func� on and a� en� on, and informa� on processing speed. PARAMETERS: The eight-week prospec� ve, randomized, double-blind, placebo-controlled study included 50 healthy adults over age 35; exclusion criteria included moderate/severe memory impairment, known neuropsychiatric condi� ons, persistent endocrine disorders and severe co-morbid medical condi� ons. The use of nootropic agents, memory enhancing drugs or alterna� ve medicines was prohibited during the study. Par� cipants received a full-spectrum root extract of ashwagandha (as KSM-66 Ashwagandha from Ixoreal Biomed), receiving 300 mg per dose, twice daily, or placebo capsules twice daily. Effi cacy parameters were judged using the Wechsler Memory Scale III scores for memory and cogni� on domains. No diff erences between groups were seen in vital parameters at baseline. THEORY: Ashwagandha (Withania somnifera Dunal) has a long history of use as an adaptogen, helping to counteract the nega� ve eff ects of stress on the body. Various bioac� ves in ashwagandha have been shown in pre-clinical studies to impact cor� sol levels and exert anxioly� c proper� es. As previous research has connected stress to anxiety and weight gain, the ques� on was raised as to whether ashwagandha root extract could improve general well-being and reduce physiological markers of stress that have been associated with obesity, reducing hunger and stress-ea� ng behaviors to impact weight and improve general well-being. PARAMETERS: The eight-week prospec� ve clinical trial, conducted at a study center in Pune, India, involved 52 men and women between 18 and 60 years, who had a Perceived Stress Scale (PSS) score greater than 20, sugges� ng chronic stress symptoms, and a body mass index (BMI) between 25 and 39.9. The trial was conducted using a random assignment, parallel-group, double-blind, placebo-controlled design, in which the par� cipants received a full-spectrum root extract of ashwagandha (as KSM-66 Ashwagandha from Ixoreal Biomed), receiving 300 mg per dose, twice daily, or placebo capsules twice daily. Primary outcomes were measured with the PSS score and Food Cravings Ques� onnaire-Trait (FCQ), with secondary outcomes related to weight, BMI, serum cor� sol levels and happiness. OUTCOME: At the end of the eight weeks, par� cipants taking ashwagandha had a: Ashwagandha Improves Memory, Cogni� ve Func� on Ashwagandha The Stress/Weight Management Connec� on OUTCOME: At the end of the eight weeks, for the par� cipants taking ashwagandha:

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